Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1

Ai Guo Wang, Sang Beom Seo, Hyung Bae Moon, Hye Jun Shin, Dong Hoon Kim, Jin Man Kim, Tae Hoon Lee, Ho Jeong Kwon, Dae Yeul Yu, Dong Seok Lee

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway.

Original languageEnglish
Pages (from-to)461-466
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 2005 May 6

Bibliographical note

Funding Information:
This work was supported by the 21st Century Frontier Functional Human Genome Project of Korea, Grant No. HGC0300324 and the Ministry of Health and Welfare of Korea, Grant No. 02-PJ2-PG1-CH12-0002.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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