Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief

Hye Yeong Lee; Gi Yoong Tae; Sae Yeon Hwang; Sung Won Wee; Yoon Ha; Hye Lan Lee; Dong Ah Shin

doi:10.3390/biomedicines11051436

Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief

Hye Yeong Lee, Gi Yoong Tae, Sae Yeon Hwang, Sung Won Wee, Yoon Ha, Hye Lan Lee, Dong Ah Shin

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

This study explores the therapeutic efficacy of heparin-based hydrogel micropatches containing human adipose-derived stem cells (hASCs) in treating neuropathic pain caused by nerve damage. Our results showed that hASCs exhibited neuroregenerative and pain-relieving effects when used with heparin-based hydrogel micropatches in the neuropathic pain animal model. The use of this combination also produced enhanced cell viability and nerve regeneration. We conducted various neurological behavioral tests, dynamic plantar tests, histological examinations, and neuroelectrophysiological examinations to confirm the therapeutic effect. Our findings suggest that this approach could maximize therapeutic efficacy and improve the quality of life for patients suffering from neuropathic pain.

Original language	English
Article number	1436
Journal	Biomedicines
Volume	11
Issue number	5
DOIs	https://doi.org/10.3390/biomedicines11051436
Publication status	Published - 2023 May

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
General Biochemistry,Genetics and Molecular Biology

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10.3390/biomedicines11051436

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title = "Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief",

abstract = "This study explores the therapeutic efficacy of heparin-based hydrogel micropatches containing human adipose-derived stem cells (hASCs) in treating neuropathic pain caused by nerve damage. Our results showed that hASCs exhibited neuroregenerative and pain-relieving effects when used with heparin-based hydrogel micropatches in the neuropathic pain animal model. The use of this combination also produced enhanced cell viability and nerve regeneration. We conducted various neurological behavioral tests, dynamic plantar tests, histological examinations, and neuroelectrophysiological examinations to confirm the therapeutic effect. Our findings suggest that this approach could maximize therapeutic efficacy and improve the quality of life for patients suffering from neuropathic pain.",

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AU - Lee, Hye Yeong

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AU - Hwang, Sae Yeon

AU - Wee, Sung Won

AU - Ha, Yoon

AU - Lee, Hye Lan

AU - Shin, Dong Ah

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N2 - This study explores the therapeutic efficacy of heparin-based hydrogel micropatches containing human adipose-derived stem cells (hASCs) in treating neuropathic pain caused by nerve damage. Our results showed that hASCs exhibited neuroregenerative and pain-relieving effects when used with heparin-based hydrogel micropatches in the neuropathic pain animal model. The use of this combination also produced enhanced cell viability and nerve regeneration. We conducted various neurological behavioral tests, dynamic plantar tests, histological examinations, and neuroelectrophysiological examinations to confirm the therapeutic effect. Our findings suggest that this approach could maximize therapeutic efficacy and improve the quality of life for patients suffering from neuropathic pain.

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Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief

Abstract

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