Hemoglobin and mortality in patients with COPD: A nationwide population-based cohort study

Seon Cheol Park, Young Sam Kim, Young Ae Kang, Eun Cheol Park, Cheung Soo Shin, Dong Wook Kim, Chin Kook Rhee

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Purpose: Previous studies have reported that anemia increased mortality in patients with COPD. However, it is unclear whether anemia is associated with increased COPD mortality in the general population. The purpose of our study is to identify whether anemia is related to long-term mortality in COPD using a large population-based database. Patients and methods: Using the National Health Insurance Service-Health Screening Cohort, we identified COPD patients with available hemoglobin level. We analyzed mortality among patients with COPD from 2003 to 2013 according to hemoglobin level. Results: A total of 7,114 patients with COPD were identified. Mean age was 65.0±9.3 years, and 62.9% were male. Anemia was present in 469 patients (6.6%). The overall mortality rate was 46.5% in anemia and 32.1% in non-anemia groups (p<0.001). The hazard ratio of anemia for mortality was 1.31 (95% CI, 1.11–1.54). Among patients with anemia, the hemoglobin level correlated well with mortality. Conclusion: Anemia was associated with increased long-term mortality of COPD, and even mild anemia was related to a significantly increased risk.

Original languageEnglish
Pages (from-to)1599-1605
Number of pages7
JournalInternational Journal of COPD
Publication statusPublished - 2018 May 16

Bibliographical note

Publisher Copyright:
© 2018 Park et al.

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health


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