Hemodynamic and Prognostic Implications of Net Atrioventricular Compliance in Patients with Mitral Stenosis

Hyung Kwan Kim, Yong Jin Kim, Seok Jae Hwang, Jin Shik Park, Hyuk Jae Chang, Dae Won Sohn, Byung Hee Oh, Young Bae Park

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Background: On the basis of the close association of left atrial compliance with pulmonary hypertension in patients with mitral stenosis, we hypothesized that: (1) Doppler-derived net atrioventricular compliance (Cn) can be used for predicting the occurrence of mitral valve (MV) replacement or percutaneous mitral commissurotomy (PMC); and (2) determinants of exercise capacity are variable depending on Cn. Methods: We consecutively enrolled 26 patients (22 women; mean age, 47.0 ± 6.1 years; range, 35-59 years) with pure moderate or severe mitral stenosis, in whom comprehensive echocardiography was performed at rest. Cn was derived from the equation that has been previously validated (ie, Cn = 1270 × [MV area by 2-dimensional planimetry/mitral E-wave downslope]. Measurements of stroke volume and systolic pulmonary artery pressure were repeated immediately after symptom-limited treadmill exercise test within 60 seconds. Results: On the basis of earlier reports, Cn less than 4 mL/mm Hg was selected to define abnormally small Cn. During a mean duration of 24-month follow-up, Cn of less than 4 mL/mm Hg could reliably predict the occurrence of either MV replacement or PMC, which was confirmed by multivariate logistic regression analysis. In patients with Cn less than 4 mL/mm Hg, exercise duration was found to be closely correlated primarily with resting systolic pulmonary artery pressure (r = -0.73, P = .03), whereas in patients with Cn greater than or equal to 4 mL/mm Hg, postexercise stroke volume was the only determinant of exercise capacity (r = 0.49, P = .04). When combining Cn less than 4 mL/mm Hg with MV area less than 1.0 cm2 as a cut-off value for predicting MV replacement or PMC, the sensitivity improved from 63.6% to 81.8% (P = .05). Conclusions: Left atrial compliance estimated by Cn with Doppler echocardiography allows us to effectively predict the future occurrence of MV replacement or PMC, with a special usefulness in patients with moderate mitral stenosis. In addition, determinants of exercise capacity were variable depending on the degree of Cn.

Original languageEnglish
Pages (from-to)482-486
Number of pages5
JournalJournal of the American Society of Echocardiography
Issue number5
Publication statusPublished - 2008 May

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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