TY - JOUR
T1 - Helicobacter pylori eradication on the prevention of metachronous lesions after endoscopic resection of gastric neoplasm
T2 - A meta-analysis
AU - Jung, Da Hyun
AU - Kim, Jie Hyun
AU - Chung, Hyun Soo
AU - Park, Jun Chul
AU - Shin, Sung Kwan
AU - Lee, Sang Kil
AU - Lee, Yong Chan
N1 - Publisher Copyright:
© 2015 Jung et al.
PY - 2015/4/27
Y1 - 2015/4/27
N2 - Background: There is controversy about the effect of Helicobacter pylori (H. pylori) eradication on the prevention of metachronous gastric cancer after endoscopic resection (ER). Aims: The aim of this study was to systematically evaluate the effect of H. pylori eradication on the prevention of metachronous gastric lesions after ER of gastric neoplasms. Methods: We performed a systematic search of PubMed, EMBASE, the Cochrane Library, and MEDLINE that encompassed studies through April 2014. Our meta-analysis consisted of 10 studies, which included 5881 patients who underwent ER of gastric neoplasms. Results: When we compared the incidence of metachronous lesions between H. pylori-eradicated and non-eradicated groups, H. pylori eradication significantly lowered the risk of metachronous lesions after ER of gastric neoplasms (five studies, OR = 0.392, 95% CI 0.259-0.593, P < 0.001). When we compared H. pylori-eradicated and persistent groups, again, H. pylori eradication significantly lowered the incidence of metachronous lesions after ER of gastric neoplasms (six studies, OR = 0.468, 95% CI 0.326-0.673, P < 0.001). There was no obvious heterogeneity across the analyzed studies. Conclusions: This meta-analysis suggests a preventive role for H. pylori eradication for metachronous gastric lesions after ER of gastric neoplasms. Thus, H. pylori eradication should be considered if H. pylori infection is confirmed during ER.
AB - Background: There is controversy about the effect of Helicobacter pylori (H. pylori) eradication on the prevention of metachronous gastric cancer after endoscopic resection (ER). Aims: The aim of this study was to systematically evaluate the effect of H. pylori eradication on the prevention of metachronous gastric lesions after ER of gastric neoplasms. Methods: We performed a systematic search of PubMed, EMBASE, the Cochrane Library, and MEDLINE that encompassed studies through April 2014. Our meta-analysis consisted of 10 studies, which included 5881 patients who underwent ER of gastric neoplasms. Results: When we compared the incidence of metachronous lesions between H. pylori-eradicated and non-eradicated groups, H. pylori eradication significantly lowered the risk of metachronous lesions after ER of gastric neoplasms (five studies, OR = 0.392, 95% CI 0.259-0.593, P < 0.001). When we compared H. pylori-eradicated and persistent groups, again, H. pylori eradication significantly lowered the incidence of metachronous lesions after ER of gastric neoplasms (six studies, OR = 0.468, 95% CI 0.326-0.673, P < 0.001). There was no obvious heterogeneity across the analyzed studies. Conclusions: This meta-analysis suggests a preventive role for H. pylori eradication for metachronous gastric lesions after ER of gastric neoplasms. Thus, H. pylori eradication should be considered if H. pylori infection is confirmed during ER.
UR - http://www.scopus.com/inward/record.url?scp=84928607087&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928607087&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0124725
DO - 10.1371/journal.pone.0124725
M3 - Article
C2 - 25915048
AN - SCOPUS:84928607087
SN - 1932-6203
VL - 10
JO - PloS one
JF - PloS one
IS - 4
M1 - e0124725
ER -
