Health surveillance of specific pathogen-free and conventionally-housed mice and rats in Korea

Seunghyeok Seok, Jonghwan H. Park, Suna Cho, Minwon Baek, Huiyoung Lee, Dongjae Kim, Kihwa Yang, Dongdeuk Jang, Beomseok Han, Kitaek Nam, Jaehak Park

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The present study contains information about proper microbiological monitoring of laboratory animals' health and the standardization of microbiological monitoring methods in Korea. Microbiological quality control for laboratory animals, composed of biosecurity and health surveillance, is essential to guard against research complications and public health dangers that have been associated with adventitious infections. In this study, one hundred and twenty-two mice and ninety rats from laboratory animal breeding companies and one animal facility of the national universities in Korea were monitored in 2000-2003. Histopathologically, thickening of the alveolar walls and lymphocytic infiltration around the bronchioles were observed in mice and rats from microbiologically contaminated facilities. Cryptosporidial oocysts were observed in the gastric pits of only conventionally-housed mice and rats. Helicobacter spp. infection was also detected in 1 of 24 feces DNA samples in mice and 9 of 40 feces DNA samples in rats by PCR in 2003, but they were not Helicobacter hepaticus. This paper describes bacteriological, parasitological, and virological examinations of the animals.

Original languageEnglish
Pages (from-to)85-92
Number of pages8
JournalExperimental Animals
Issue number1
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)


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