Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells

Tapas R. Nayak, Henrik Andersen, Venkata S. Makam, Clement Khaw, Sukang Bae, Xiangfan Xu, Pui Lai R. Ee, Jong Hyun Ahn, Byung Hee Hong, Giorgia Pastorin, Barbaros Özyilmaz

Research output: Contribution to journalArticlepeer-review

811 Citations (Scopus)


Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful is to direct stem cells proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate is comparable to the one achieved with common growth factors, demonstrating graphenes potential for stem cell research.

Original languageEnglish
Pages (from-to)4670-4678
Number of pages9
JournalACS Nano
Issue number6
Publication statusPublished - 2011 Jun 28

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


Dive into the research topics of 'Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells'. Together they form a unique fingerprint.

Cite this