Golgi polarization plays a role in the directional migration of neonatal dermal fibroblasts induced by the direct current electric fields

Min Sung Kim; Mi Hee Lee; Byeong Ju Kwon; Min Ah Koo; Gyeung Mi Seon; Jong Chul Park

doi:10.1016/j.bbrc.2015.03.021

Golgi polarization plays a role in the directional migration of neonatal dermal fibroblasts induced by the direct current electric fields

Min Sung Kim, Mi Hee Lee, Byeong Ju Kwon, Min Ah Koo, Gyeung Mi Seon, Jong Chul Park

Department of Medical Engineering

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Directional cell migration requires cell polarization. The reorganization of the Golgi apparatus is an important phenomenon in the polarization and migration of many types of cells. Direct current electric fields (dc (EF) induced directional cell migration in a wide variety of cells. Here nHDFs migrated toward cathode under 1 V/cm dc EF, however 1 μM of brefeldin A (BFA) inhibited the dc EF induced directional migration. BFA (1 μM) did not cause the complete Golgi dispersal for 2 h. When the Golgi polarization maintained their direction of polarity, the direction of cell migration also kept toward the same direction of the Golgi polarization even though the dc EF was reversed. In this study, the importance of the Golgi polarization in the directional migration of nHDf under dc EF was identified.

Original language	English
Pages (from-to)	255-260
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	460
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2015.03.021
Publication status	Published - 2015 May 1

Bibliographical note

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© 2015 Elsevier Inc. All rights reserved.

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2015.03.021

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abstract = "Directional cell migration requires cell polarization. The reorganization of the Golgi apparatus is an important phenomenon in the polarization and migration of many types of cells. Direct current electric fields (dc (EF) induced directional cell migration in a wide variety of cells. Here nHDFs migrated toward cathode under 1 V/cm dc EF, however 1 μM of brefeldin A (BFA) inhibited the dc EF induced directional migration. BFA (1 μM) did not cause the complete Golgi dispersal for 2 h. When the Golgi polarization maintained their direction of polarity, the direction of cell migration also kept toward the same direction of the Golgi polarization even though the dc EF was reversed. In this study, the importance of the Golgi polarization in the directional migration of nHDf under dc EF was identified.",

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AU - Lee, Mi Hee

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AU - Koo, Min Ah

AU - Seon, Gyeung Mi

AU - Park, Jong Chul

PY - 2015/5/1

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AB - Directional cell migration requires cell polarization. The reorganization of the Golgi apparatus is an important phenomenon in the polarization and migration of many types of cells. Direct current electric fields (dc (EF) induced directional cell migration in a wide variety of cells. Here nHDFs migrated toward cathode under 1 V/cm dc EF, however 1 μM of brefeldin A (BFA) inhibited the dc EF induced directional migration. BFA (1 μM) did not cause the complete Golgi dispersal for 2 h. When the Golgi polarization maintained their direction of polarity, the direction of cell migration also kept toward the same direction of the Golgi polarization even though the dc EF was reversed. In this study, the importance of the Golgi polarization in the directional migration of nHDf under dc EF was identified.

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Golgi polarization plays a role in the directional migration of neonatal dermal fibroblasts induced by the direct current electric fields

Abstract

Bibliographical note

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