Glioblastoma cellular origin and the firework pattern of cancer genesis from the subventricular zone

Seon Jin Yoon, Junseong Park, Dong Su Jang, Hyun Jung Kim, Joo Ho Lee, Euna Jo, Ran Joo Choi, Jin Kyung Shim, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Jeong Ho Lee, Seok Gu Kang

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


Glioblastoma (GBM) is a disease without any definite cure. Numerous approaches have been tested in efforts to conquer this brain disease, but patients invariably experience recurrence or develop resistance to treatment. New surgical tools, carefully chosen samples, and experimental methods are enabling discoveries at single-cell resolution. The present article reviews the cell-of-origin of isocitrate dehydrogenase (IDH)-wildtype GBM, beginning with the historical background for focusing on cellular origin and introducing the cancer genesis patterned on firework. The authors also review mutations associated with the senescence process in cells of the subventricular zone (SVZ), and biological validation of somatic mutations in a mouse SVZ model. Understanding GBM would facilitate research on the origin of other cancers and may catalyze the development of new management approaches or treatments against IDH-wildtype GBM.

Original languageEnglish
Pages (from-to)26-33
Number of pages8
JournalJournal of Korean Neurosurgical Society
Issue number1
Publication statusPublished - 2020 Jan

Bibliographical note

Funding Information:
This work was supported by grants from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI17C2586), the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (NRF-2019R1A2C3004155), and the NRF grant funded by the MSIP : Ministry of Science, ICT and Future Planning, Republic of Korea (NRF-2017M2A2A7A01071).

Publisher Copyright:
© 2020 The Korean Neurosurgical Society.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neuroscience(all)
  • Clinical Neurology


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