Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates

Su Young Kim; Byung Woo Jhun; Seong Mi Moon; Kyeongman Jeon; O. Jung Kwon; Hee Jae Huh; Nam Yong Lee; Sung Jae Shin; Charles L. Daley; Won Jung Koh

doi:10.1016/j.diagmicrobio.2018.10.022

Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates

Su Young Kim, Byung Woo Jhun, Seong Mi Moon, Kyeongman Jeon, O. Jung Kwon, Hee Jae Huh, Nam Yong Lee, Sung Jae Shin, Charles L. Daley, Won Jung Koh

Department of Microbiology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

There are no studies evaluating the mechanisms driving linezolid resistance in nontuberculous mycobacteria. The novel mutations G2599A and A2137T in the 23S rRNA gene and mutations A439G and G443A in the rplD gene associated with linezolid resistance were identified in linezolid-resistant M. avium complex isolates.

Original language	English
Pages (from-to)	38-40
Number of pages	3
Journal	Diagnostic Microbiology and Infectious Disease
Volume	94
Issue number	1
DOIs	https://doi.org/10.1016/j.diagmicrobio.2018.10.022
Publication status	Published - 2019 May

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, Information and Communications Technologies (NRF-2018R1A2A1A05018309 to W-J. K.), and by the Basic Science Research Program through the NRF funded by the Ministry of Education ( NRF-2016R1A6A3A11930364 to S.-Y.K.).

Publisher Copyright:
© 2018 Elsevier Inc.

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diagmicrobio.2018.10.022

Cite this

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title = "Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates",

abstract = "There are no studies evaluating the mechanisms driving linezolid resistance in nontuberculous mycobacteria. The novel mutations G2599A and A2137T in the 23S rRNA gene and mutations A439G and G443A in the rplD gene associated with linezolid resistance were identified in linezolid-resistant M. avium complex isolates.",

author = "Kim, {Su Young} and Jhun, {Byung Woo} and Moon, {Seong Mi} and Kyeongman Jeon and Kwon, {O. Jung} and Huh, {Hee Jae} and Lee, {Nam Yong} and Shin, {Sung Jae} and Daley, {Charles L.} and Koh, {Won Jung}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, Information and Communications Technologies (NRF-2018R1A2A1A05018309 to W-J. K.), and by the Basic Science Research Program through the NRF funded by the Ministry of Education ( NRF-2016R1A6A3A11930364 to S.-Y.K.). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = may,

doi = "10.1016/j.diagmicrobio.2018.10.022",

language = "English",

volume = "94",

pages = "38--40",

journal = "Diagnostic Microbiology and Infectious Disease",

issn = "0732-8893",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates

AU - Kim, Su Young

AU - Jhun, Byung Woo

AU - Moon, Seong Mi

AU - Jeon, Kyeongman

AU - Kwon, O. Jung

AU - Huh, Hee Jae

AU - Lee, Nam Yong

AU - Shin, Sung Jae

AU - Daley, Charles L.

AU - Koh, Won Jung

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, Information and Communications Technologies (NRF-2018R1A2A1A05018309 to W-J. K.), and by the Basic Science Research Program through the NRF funded by the Ministry of Education ( NRF-2016R1A6A3A11930364 to S.-Y.K.). Publisher Copyright: © 2018 Elsevier Inc.

PY - 2019/5

Y1 - 2019/5

N2 - There are no studies evaluating the mechanisms driving linezolid resistance in nontuberculous mycobacteria. The novel mutations G2599A and A2137T in the 23S rRNA gene and mutations A439G and G443A in the rplD gene associated with linezolid resistance were identified in linezolid-resistant M. avium complex isolates.

AB - There are no studies evaluating the mechanisms driving linezolid resistance in nontuberculous mycobacteria. The novel mutations G2599A and A2137T in the 23S rRNA gene and mutations A439G and G443A in the rplD gene associated with linezolid resistance were identified in linezolid-resistant M. avium complex isolates.

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DO - 10.1016/j.diagmicrobio.2018.10.022

M3 - Article

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SN - 0732-8893

VL - 94

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JO - Diagnostic Microbiology and Infectious Disease

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Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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