Generation of two induced pluripotent stem cell (iPSC) lines from X-linked adrenoleukodystrophy (X-ALD) patients with adrenomyeloneuropathy (AMN)

Daryeon Son; Zhejiu Quan; Phil Jun Kang; Gyuman Park; Hoon Chul Kang; Seungkwon You

doi:10.1016/j.scr.2017.10.003

Generation of two induced pluripotent stem cell (iPSC) lines from X-linked adrenoleukodystrophy (X-ALD) patients with adrenomyeloneuropathy (AMN)

Daryeon Son, Zhejiu Quan, Phil Jun Kang, Gyuman Park, Hoon Chul Kang, Seungkwon You

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by a mutation in the ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene. We generated two induced pluripotent stem cell (iPSC) lines from X-ALD patients with adrenomyeloneuropathy (AMN) by Sendai virus containing OCT4, SOX2, KLF4 and c-MYC. Established iPSC lines expressed various pluripotency markers, had differentiation potential of three germ layers in vitro, had normal karyotype and retained ABCD1 mutation.

Original language	English
Pages (from-to)	46-49
Number of pages	4
Journal	Stem Cell Research
Volume	25
DOIs	https://doi.org/10.1016/j.scr.2017.10.003
Publication status	Published - 2017 Dec

Bibliographical note

Publisher Copyright:
© 2017 The Authors

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

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abstract = "X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by a mutation in the ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene. We generated two induced pluripotent stem cell (iPSC) lines from X-ALD patients with adrenomyeloneuropathy (AMN) by Sendai virus containing OCT4, SOX2, KLF4 and c-MYC. Established iPSC lines expressed various pluripotency markers, had differentiation potential of three germ layers in vitro, had normal karyotype and retained ABCD1 mutation.",

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AU - Quan, Zhejiu

AU - Kang, Phil Jun

AU - Park, Gyuman

AU - Kang, Hoon Chul

AU - You, Seungkwon

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Generation of two induced pluripotent stem cell (iPSC) lines from X-linked adrenoleukodystrophy (X-ALD) patients with adrenomyeloneuropathy (AMN)

Abstract

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