Gastric retentive drug-delivery systems

Sung Joo Hwang, Haesun Park, Kinam Park

Research output: Contribution to journalArticlepeer-review

175 Citations (Scopus)


The development of a long-term oral controlled-release dosage form has been difficult mainly because of the transit of the dosage form through the gastrointestinal (GI) tract. Several approaches to extend gastric residence time have been tried. The most commonly used systems are (1) intragastric floating systems, (2) high-density systems, (3) mucoadhesive systems, (4) magnetic systems, (5) unfoldable, extendible, or swellable systems, and (6) superporous hydrogel systems. The concept of each approach is examined, and improvements that are needed for further development are discussed. Background materials in the GI physiology that are necessary for understanding the concept and usefulness of each approach are also provided.

Original languageEnglish
Pages (from-to)243-284
Number of pages42
JournalCritical Reviews in Therapeutic Drug Carrier Systems
Issue number3
Publication statusPublished - 1998

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science


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