Gamma knife surgery for multiple hemangioblastomas

Sook Park Yong, Hee Chang Jong, Woo Chang Jin, Sup Chung Sang, Gou Park Yong

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Object. The authors describe their experience in treating patients with hemangioblastoma, especially multiple lesions, with gamma knife surgery (GKS). Methods. Nine patients with 84 hemangioblastomas underwent GKS between July 1992 and May 2003. Three patients harbored a single lesion and six patients had multiple lesions. Of the six patients with multifocal tumors, a diagnosis of von Hippel-Lindau disease had been established in five. In the patients with multiple lesions, the mean radiation dose delivered to the tumor margin was 16.6 Gy (range 12.8-29.75 Gy). The mean margin isodose was 60% (range 40-95%). Three of the 84 lesions failed to be controlled after a mean follow-up period of 4.3 years (range 8.6-141 months). One patient who had undergone two GKS treatments suffered delayed radiation-induced complications, and posterior fossa decompression and ventriculoperitoneal shunt insertion were required. Conclusions. To achieve tumor control and avoid morbidity, the surgeon should keep in mind minimizing field overlapping by using a small-diameter collimator or applying a steep dose gradient, and by accurate dose prescription.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalJournal of neurosurgery
Issue numberSUPPL.
Publication statusPublished - 2005 Jan

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology


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