G-T haplotype (2677G > T/A and 3435C > T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern

Woo Sun Kwon; Sun Young Rha; Hei Cheul Jeung; Joong Bae Ahn; Jae Joon Jung; Sung Hoon Noh; Hyun Cheol Chung

doi:10.1016/j.canlet.2008.12.001

G-T haplotype (2677G > T/A and 3435C > T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern

Woo Sun Kwon, Sun Young Rha, Hei Cheul Jeung, Joong Bae Ahn, Jae Joon Jung, Sung Hoon Noh, Hyun Cheol Chung

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

At 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p = 0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p = 0.018). A higher IC₅₀ was found in GG than GT/A genotype (p = 0.02) and in G-C than G-T haplotype (p = 0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p = 0.01) due to different polymorphism frequencies. We identified 65 genes that were differently expressed in cell lines of the G-C and G-T ABCB1 haplotypes. Ethnic differences in the G-T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity, and future clinical validation is necessary to confirm our findings. Crown

Original language	English
Pages (from-to)	155-163
Number of pages	9
Journal	Cancer Letters
Volume	277
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2008.12.001
Publication status	Published - 2009 May 18

Bibliographical note

Funding Information:
This study was supported by a Grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (0405-BC01-0604-0002).

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2008.12.001

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@article{b2c227e33e2f42c1a4a405909d0015a9,

title = "G-T haplotype (2677G > T/A and 3435C > T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern",

abstract = "At 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p = 0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p = 0.018). A higher IC50 was found in GG than GT/A genotype (p = 0.02) and in G-C than G-T haplotype (p = 0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p = 0.01) due to different polymorphism frequencies. We identified 65 genes that were differently expressed in cell lines of the G-C and G-T ABCB1 haplotypes. Ethnic differences in the G-T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity, and future clinical validation is necessary to confirm our findings. Crown",

author = "Kwon, {Woo Sun} and Rha, {Sun Young} and Jeung, {Hei Cheul} and Ahn, {Joong Bae} and Jung, {Jae Joon} and Noh, {Sung Hoon} and Chung, {Hyun Cheol}",

note = "Funding Information: This study was supported by a Grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (0405-BC01-0604-0002). ",

year = "2009",

month = may,

day = "18",

doi = "10.1016/j.canlet.2008.12.001",

language = "English",

volume = "277",

pages = "155--163",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

G-T haplotype (2677G > T/A and 3435C > T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern. / Kwon, Woo Sun; Rha, Sun Young; Jeung, Hei Cheul et al.
In: Cancer Letters, Vol. 277, No. 2, 18.05.2009, p. 155-163.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - G-T haplotype (2677G > T/A and 3435C > T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern

AU - Kwon, Woo Sun

AU - Rha, Sun Young

AU - Jeung, Hei Cheul

AU - Ahn, Joong Bae

AU - Jung, Jae Joon

AU - Noh, Sung Hoon

AU - Chung, Hyun Cheol

N1 - Funding Information: This study was supported by a Grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (0405-BC01-0604-0002).

PY - 2009/5/18

Y1 - 2009/5/18

N2 - At 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p = 0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p = 0.018). A higher IC50 was found in GG than GT/A genotype (p = 0.02) and in G-C than G-T haplotype (p = 0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p = 0.01) due to different polymorphism frequencies. We identified 65 genes that were differently expressed in cell lines of the G-C and G-T ABCB1 haplotypes. Ethnic differences in the G-T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity, and future clinical validation is necessary to confirm our findings. Crown

AB - At 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p = 0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p = 0.018). A higher IC50 was found in GG than GT/A genotype (p = 0.02) and in G-C than G-T haplotype (p = 0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p = 0.01) due to different polymorphism frequencies. We identified 65 genes that were differently expressed in cell lines of the G-C and G-T ABCB1 haplotypes. Ethnic differences in the G-T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity, and future clinical validation is necessary to confirm our findings. Crown

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G-T haplotype (2677G > T/A and 3435C > T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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