Functional remodeling after vocal fold injury by small intestinal submucosa gel containing hepatocyte growth factor

Jeong Seok Choi, Songyi Lee, Da Yeon Kim, Young Mo Kim, Moon Suk Kim, Jae Yol Lim

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


A biomaterial derived from porcine small intestinal submucosa (SIS) was used in smart drug delivery and tissue remodeling. SIS suspensions were easily formulated by simple mixing with the drug of choice and formed an in situ gel upon injection into tissues, enabling them to act as protein drug depots. This study was conducted to determine whether functional remodeling of an injured vocal fold (VF) could be achieved by hepatocyte growth factor (HGF)-containing SIS in situ-forming gel after VF injury in a rabbit model. To accomplish this, we loaded HGF in SIS suspensions and observed a gradual, sustained release of HGF for at least 21 days invitro. Evaluation of the invivo efficacy demonstrated that the HGF and HGF-loaded SIS treated VFs showed improved mucosal healing when compared with the PBS-injected VFs. Histopathological evaluations revealed that treatment with the HGF/SIS group alone successfully ameliorated the deposition of type I collagen and increased synthesis of hyaluronic acids relative to the PBS group at three months post-injury. Functional analyses showed that the HGF/SIS group prevented deterioration of mucosal vibration and induced significant improvement in the mean viscoelastic modulus, but that other groups failed to achieve functional rescue of VF biomechanics. Additionally, the VF oscillation in the HGF/SIS group was superior to that in the HGF group. The results of this study suggest that SIS in situ gel has the potential for use as an HGF delivery carrier for enhancement of wound healing and improvement of functional remodeling following VF injury.

Original languageEnglish
Pages (from-to)98-106
Number of pages9
Publication statusPublished - 2015 Feb 1

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program of the National Research Foundation ( NRF-2013R1A2A2A04014200 ) funded by the Korean Ministry of Education, Science and Technology and an Inha University Research Grant.

Publisher Copyright:
© 2014 Elsevier Ltd.

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials


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