Functional electrical stimulation exercise increases GLUT-1 and GLUT-4 in paralyzed skeletal muscle

Philip D. Chilibeck, Gordon Bell, Justin Jeon, Christina B. Weiss, Gordon Murdoch, Ian MacLean, Edmond Ryan, Robert Burnham

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)


The study purpose was to determine the effect of functional electrical stimulation (FES)-leg cycle ergometer training (30 minutes on 3 d/wk for 8 weeks) on the GLUT-1 and GLUT-4 content of paralyzed skeletal muscle. Biopsy samples of vastus lateralis muscle were obtained pre- and post-training from five individuals with motor-complete spinal cord injury ([SCI] four men and one woman aged 31 to 50 years, 3 to 25 years postinjury involving C5-T8). Western blot analysis indicated that GLUT-1 increased by 52% and GLUT-4 increased by 72% with training (P < .05). This coincided with an increase in the muscle oxidative capacity as indicated by a 56% increase in citrate synthase (CS) activity (P < .05) and an improvement in the insulin sensitivity index as determined from oral glucose tolerance tests (P < .05). It is concluded that FES endurance training is effective to increase glucose transporter protein levels in paralyzed skeletal muscle of individuals with SCI.

Original languageEnglish
Pages (from-to)1409-1413
Number of pages5
JournalMetabolism: Clinical and Experimental
Issue number11
Publication statusPublished - 1999

Bibliographical note

Funding Information:
From the Faculty of Physical Education and Recreation, Faculty of Medicine, and the Rick Hansen Centre, University of Alberta, Edmonton, Alberta, Canada. Submitted December 10, 1998; accepted May 25, 1999. Supported by a grant from the Glenrose Rehabilitation Hospital (Edmonton, Alberta, Canada), the Alberta Paraplegic Foundation, and Therapeutic Alliance (Fairborn, OH). Address reprint requests to Philip D. Chilibeck, PhD, College of Kinesiology, University of Saskatchewan, 105 Gymnasium Place, Saskatoon, Saskatchewan, Canada S7N 5C2. Copyright © 1999 by W.B. Saunders Company 0026-0495/99/4811-0013510.00/0

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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