Functional disconnection of the semantic networks in schizophrenia

Jae Jin Kim, Ho Seok Jeong, Hae Jeong Park, Soo Lee Dong, Chul Lee Myung, Soo Kwon Jun

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Patients with schizophrenia exhibit deficits in semantic processing, which can form the basis of thought disorders. The objective of this study was to explore functional connectivity between the activated areas during semantic processing in schizophrenia. Twelve patients with schizophrenia and 12 healthy controls were studied with [ 15O]H 2O positron-emission tomography during semantic judgment. The expected activation in the left inferior occipitotemporal cortex significantly correlated with several other regional activations in normal study participants, but with no other regional activations in patients with schizophrenia. This finding suggests that schizophrenia involves a disconnection of semantic networks. The resultant distortion in semantic processing may have an impact on thought disorders.

Original languageEnglish
Pages (from-to)355-359
Number of pages5
Issue number4
Publication statusPublished - 2005 Mar 15

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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