Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis

Ho Jeon Young; Jung Weon Lee; Sunghoon Kim

doi:10.1016/j.bbapap.2016.09.009

Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis

Ho Jeon Young, Jung Weon Lee, Sunghoon Kim

Department of Pharmacy

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that conjugate specific amino acids to their cognate tRNAs for protein synthesis. Besides their catalytic activity, recent studies have uncovered many additional functions of these enzymes through their interactions with diverse cellular factors. Among human ARSs, cytosolic lysyl-tRNA synthetase (KRS) is often highly expressed in cancer cells and tissues, and facilitates cancer cell migration and invasion through the interaction with the 67 kDa laminin receptor on the plasma membrane. Specific modulation of this interaction by small molecule inhibitors has revealed a new way to control metastasis. Here, we summarize the pro-metastatic functions of KRS and their patho-physiological implications.

Original language	English
Pages (from-to)	1707-1713
Number of pages	7
Journal	Biochimica et Biophysica Acta - Proteins and Proteomics
Volume	1864
Issue number	12
DOIs	https://doi.org/10.1016/j.bbapap.2016.09.009
Publication status	Published - 2016 Dec 1

Bibliographical note

Publisher Copyright:
© 2016

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biophysics
Biochemistry
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbapap.2016.09.009

Cite this

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title = "Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis",

abstract = "Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that conjugate specific amino acids to their cognate tRNAs for protein synthesis. Besides their catalytic activity, recent studies have uncovered many additional functions of these enzymes through their interactions with diverse cellular factors. Among human ARSs, cytosolic lysyl-tRNA synthetase (KRS) is often highly expressed in cancer cells and tissues, and facilitates cancer cell migration and invasion through the interaction with the 67 kDa laminin receptor on the plasma membrane. Specific modulation of this interaction by small molecule inhibitors has revealed a new way to control metastasis. Here, we summarize the pro-metastatic functions of KRS and their patho-physiological implications.",

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AU - Young, Ho Jeon

AU - Lee, Jung Weon

AU - Kim, Sunghoon

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Y1 - 2016/12/1

N2 - Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that conjugate specific amino acids to their cognate tRNAs for protein synthesis. Besides their catalytic activity, recent studies have uncovered many additional functions of these enzymes through their interactions with diverse cellular factors. Among human ARSs, cytosolic lysyl-tRNA synthetase (KRS) is often highly expressed in cancer cells and tissues, and facilitates cancer cell migration and invasion through the interaction with the 67 kDa laminin receptor on the plasma membrane. Specific modulation of this interaction by small molecule inhibitors has revealed a new way to control metastasis. Here, we summarize the pro-metastatic functions of KRS and their patho-physiological implications.

AB - Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that conjugate specific amino acids to their cognate tRNAs for protein synthesis. Besides their catalytic activity, recent studies have uncovered many additional functions of these enzymes through their interactions with diverse cellular factors. Among human ARSs, cytosolic lysyl-tRNA synthetase (KRS) is often highly expressed in cancer cells and tissues, and facilitates cancer cell migration and invasion through the interaction with the 67 kDa laminin receptor on the plasma membrane. Specific modulation of this interaction by small molecule inhibitors has revealed a new way to control metastasis. Here, we summarize the pro-metastatic functions of KRS and their patho-physiological implications.

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JO - Biochimica et Biophysica Acta - Proteins and Proteomics

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ER -

Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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