Frontiers in Probing Alzheimer's Disease Biomarkers with Fluorescent Small Molecules

Yong Woong Jun, Seo Won Cho, Junyang Jung, Youngbuhm Huh, Youngsoo Kim, Dokyoung Kim, Kyo Han Ahn

Research output: Contribution to journalArticlepeer-review


Alzheimer's disease (AD) is the most common form of dementia. The pathogenesis of the disease is associated with aggregated amyloid-β, hyperphosphorylated tau, a high level of metal ions, abnormal enzyme activities, and reactive astrocytes. This outlook gives an overview of fluorescent small molecules targeting AD biomarkers for ex vivo and in vivo imaging. These chemical imaging probes are categorized based on the potential biomarkers, and their pros and cons are discussed. Guidelines for designing new sensing strategies as well as the desirable properties to be pursued for AD fluorescence imaging are also provided.
Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalACS Central Science
Issue number2
Publication statusPublished - 2019 Feb 27


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