Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography

Mark C. Pierce; Chulmin Joo; Barry Cense; Eli Weinberg; B. Hyle Park; Mircea Mujat; Jeffrey Borenstein; Guillermo J. Tearney; Brett E. Bouma; Johannes F. De Boer

doi:10.1117/12.592864

Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography

Mark C. Pierce, Chulmin Joo, Barry Cense, Eli Weinberg, B. Hyle Park, Mircea Mujat, Jeffrey Borenstein, Guillermo J. Tearney, Brett E. Bouma, Johannes F. De Boer

Department of Mechanical Engineering

Research output: Contribution to journal › Conference article › peer-review

2 Citations (Scopus)

Abstract

Microfluidic devices are becoming increasingly popular for many applications, enabling biological and chemical reactions to be performed with nano- and picoliter sample volumes. Accurate measurement and monitoring of fluid flow behavior in the small channels of microfluidic systems is important for evaluating the performance of existing devices, and in the modeling and design of new microfluidic networks. We present here the results of experiments using spectral-domain optical Doppler tomography (SD-ODT) to measure fluid flow in single-layer microfluidic devices. The principles behind flow imaging with SD-ODT are reviewed, a method for velocity calibration is described, and cross-sectional and en-face images of fluid velocity in microfluidic channels are presented.

Original language	English
Article number	47
Pages (from-to)	271-275
Number of pages	5
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	5690
DOIs	https://doi.org/10.1117/12.592864
Publication status	Published - 2005
Event	Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX - San Jose, CA, United States Duration: 2005 Jan 23 → 2005 Jan 26

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

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10.1117/12.592864

Cite this

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title = "Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography",

abstract = "Microfluidic devices are becoming increasingly popular for many applications, enabling biological and chemical reactions to be performed with nano- and picoliter sample volumes. Accurate measurement and monitoring of fluid flow behavior in the small channels of microfluidic systems is important for evaluating the performance of existing devices, and in the modeling and design of new microfluidic networks. We present here the results of experiments using spectral-domain optical Doppler tomography (SD-ODT) to measure fluid flow in single-layer microfluidic devices. The principles behind flow imaging with SD-ODT are reviewed, a method for velocity calibration is described, and cross-sectional and en-face images of fluid velocity in microfluidic channels are presented.",

author = "Pierce, {Mark C.} and Chulmin Joo and Barry Cense and Eli Weinberg and Park, {B. Hyle} and Mircea Mujat and Jeffrey Borenstein and Tearney, {Guillermo J.} and Bouma, {Brett E.} and {De Boer}, {Johannes F.}",

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journal = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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T1 - Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography

AU - Pierce, Mark C.

AU - Joo, Chulmin

AU - Cense, Barry

AU - Weinberg, Eli

AU - Park, B. Hyle

AU - Mujat, Mircea

AU - Borenstein, Jeffrey

AU - Tearney, Guillermo J.

AU - Bouma, Brett E.

AU - De Boer, Johannes F.

PY - 2005

Y1 - 2005

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AB - Microfluidic devices are becoming increasingly popular for many applications, enabling biological and chemical reactions to be performed with nano- and picoliter sample volumes. Accurate measurement and monitoring of fluid flow behavior in the small channels of microfluidic systems is important for evaluating the performance of existing devices, and in the modeling and design of new microfluidic networks. We present here the results of experiments using spectral-domain optical Doppler tomography (SD-ODT) to measure fluid flow in single-layer microfluidic devices. The principles behind flow imaging with SD-ODT are reviewed, a method for velocity calibration is described, and cross-sectional and en-face images of fluid velocity in microfluidic channels are presented.

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JO - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

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ER -

Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography

Abstract

All Science Journal Classification (ASJC) codes

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