Flecainide-associated bradycardia-dependent torsade de pointes: Another potential mechanism of proarrhythmia

Han Sang Kim; Hui Nam Pak; Jong Seoung Park; Sung Soon Kim

doi:10.1111/j.1540-8159.2010.02935.x

Flecainide-associated bradycardia-dependent torsade de pointes: Another potential mechanism of proarrhythmia

Han Sang Kim, Hui Nam Pak, Jong Seoung Park, Sung Soon Kim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Although flecainide has a risk of proarrhythmia in patients with structural heart disease, its mechanism has been mainly ascribed to use-dependency and a rapid ventricular response to organized atrial tachyarrhythmias or to ventricular tachycardia. We present a patient who experienced recurrent syncope due to bradycardia-dependent torsade de pointes (TdP) associated with flecainide-related bradycardia and QT prolongation. Bradycardia-dependent TdP with QT prolongation can be considered as one of mechanisms of flecainide-induced proarrhythmia.

Original language	English
Pages (from-to)	e84-e86
Journal	PACE - Pacing and Clinical Electrophysiology
Volume	36
Issue number	3
DOIs	https://doi.org/10.1111/j.1540-8159.2010.02935.x
Publication status	Published - 2013 Mar

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1111/j.1540-8159.2010.02935.x

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AU - Kim, Sung Soon

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AB - Although flecainide has a risk of proarrhythmia in patients with structural heart disease, its mechanism has been mainly ascribed to use-dependency and a rapid ventricular response to organized atrial tachyarrhythmias or to ventricular tachycardia. We present a patient who experienced recurrent syncope due to bradycardia-dependent torsade de pointes (TdP) associated with flecainide-related bradycardia and QT prolongation. Bradycardia-dependent TdP with QT prolongation can be considered as one of mechanisms of flecainide-induced proarrhythmia.

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Flecainide-associated bradycardia-dependent torsade de pointes: Another potential mechanism of proarrhythmia

Abstract

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