Feasibility of Left Atrial Appendage Occlusion for Left Atrial Appendage Thrombus in Patients With Persistent Atrial Fibrillation

Oh Hyun Lee, Jung Sun Kim, Hui Nam Pak, Geu Ru Hong, Chi Young Shim, Jae Sun Uhm, In Jeong Cho, Boyoung Joung, Cheol Woong Yu, Hyun Jong Lee, Woong Chol Kang, Eun Seok Shin, Rak kyeong Choi, Do Sun Lim, Yangsoo Jang

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19 Citations (Scopus)


This study sought to investigate the safety of percutaneous left atrial appendage (LAA) occlusion for stroke prevention in patients with nonvalvular atrial fibrillation who have LAA thrombus. From October 2010 to October 2016, LAA occlusions were performed in facilities within a Korean multicenter registry in patients without (n = 132) or with (n = 10) LAA thrombus (detected during preprocedural assessments). The incidences of periprocedural complications, including stroke, pericardial tamponade, major bleeding, and device embolization, were assessed and compared between the groups. The incidence of periprocedural complications was not significantly different between patients with and without LAA thrombus (0% vs 5% [6 of 132]; p = 0.49). During the mean 23.2 ± 17.5-month follow-up duration, 7 major adverse cardiac events occurred (1 cardiovascular death, 6 ischemic strokes), but overall event rates were not significantly different between the groups (14% vs 9%; p = 0.47). In conclusion, percutaneous LAA occlusion in nonvalvular atrial fibrillation patients with LAA thrombus may be a safe and feasible alternative to anticoagulation in select patients at a high risk of bleeding or contraindication to anticoagulation, or in whom anticoagulation failed to prevent stroke.

Original languageEnglish
Pages (from-to)1534-1539
Number of pages6
JournalAmerican Journal of Cardiology
Issue number12
Publication statusPublished - 2018 Jun 15

Bibliographical note

Funding Information:
This study was supported by the Cardiovascular Research Center, Seoul, South Korea. Dr. Jung-Sun Kim is a consultant for the Amplatzer cardiac plug, St. Jude Medical.

Publisher Copyright:
© 2018 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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