Fatty acid derivatives isolated from the oil of persea americana (Avocado) protects against neomycin-induced hair cell damage

Seon Ju Park; Seo Yule Jeong; Youn Hee Nam; Jun Hyung Park; Isabel Rodriguez; Ji Heon Shim; Tamanna Yasmin; Hee Jae Kwak; Youngse Oh; Mira Oh; Kye Wan Lee; Jung Suk Lee; Do Hoon Kim; Yu Hwa Park; In Seok Moon; Se Young Choung; Kwang Won Jeong; Bin Na Hong; Seung Hyun Kim; Tong Ho Kang

doi:10.3390/plants10010171

Fatty acid derivatives isolated from the oil of persea americana (Avocado) protects against neomycin-induced hair cell damage

Seon Ju Park, Seo Yule Jeong, Youn Hee Nam, Jun Hyung Park, Isabel Rodriguez, Ji Heon Shim, Tamanna Yasmin, Hee Jae Kwak, Youngse Oh, Mira Oh, Kye Wan Lee, Jung Suk Lee, Do Hoon Kim, Yu Hwa Park, In Seok Moon, Se Young Choung, Kwang Won Jeong, Bin Na Hong, Seung Hyun Kim, Tong Ho Kang

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene and (2R,4R)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish.

Original language	English
Article number	171
Pages (from-to)	1-8
Number of pages	8
Journal	Plants
Volume	10
Issue number	1
DOIs	https://doi.org/10.3390/plants10010171
Publication status	Published - 2021 Jan

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

Ecology, Evolution, Behavior and Systematics
Ecology
Plant Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/plants10010171

Cite this

Park, S. J., Jeong, S. Y., Nam, Y. H., Park, J. H., Rodriguez, I., Shim, J. H., Yasmin, T., Kwak, H. J., Oh, Y., Oh, M., Lee, K. W., Lee, J. S., Kim, D. H., Park, Y. H., Moon, I. S., Choung, S. Y., Jeong, K. W., Hong, B. N., Kim, S. H., & Kang, T. H. (2021). Fatty acid derivatives isolated from the oil of persea americana (Avocado) protects against neomycin-induced hair cell damage. Plants, 10(1), 1-8. Article 171. https://doi.org/10.3390/plants10010171

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title = "Fatty acid derivatives isolated from the oil of persea americana (Avocado) protects against neomycin-induced hair cell damage",

abstract = "Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene and (2R,4R)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish.",

author = "Park, {Seon Ju} and Jeong, {Seo Yule} and Nam, {Youn Hee} and Park, {Jun Hyung} and Isabel Rodriguez and Shim, {Ji Heon} and Tamanna Yasmin and Kwak, {Hee Jae} and Youngse Oh and Mira Oh and Lee, {Kye Wan} and Lee, {Jung Suk} and Kim, {Do Hoon} and Park, {Yu Hwa} and Moon, {In Seok} and Choung, {Se Young} and Jeong, {Kwang Won} and Hong, {Bin Na} and Kim, {Seung Hyun} and Kang, {Tong Ho}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jan,

doi = "10.3390/plants10010171",

language = "English",

volume = "10",

pages = "1--8",

journal = "Plants",

issn = "2223-7747",

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Park, SJ, Jeong, SY, Nam, YH, Park, JH, Rodriguez, I, Shim, JH, Yasmin, T, Kwak, HJ, Oh, Y, Oh, M, Lee, KW, Lee, JS, Kim, DH, Park, YH, Moon, IS, Choung, SY, Jeong, KW, Hong, BN, Kim, SH & Kang, TH 2021, 'Fatty acid derivatives isolated from the oil of persea americana (Avocado) protects against neomycin-induced hair cell damage', Plants, vol. 10, no. 1, 171, pp. 1-8. https://doi.org/10.3390/plants10010171

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AU - Park, Seon Ju

AU - Jeong, Seo Yule

AU - Nam, Youn Hee

AU - Park, Jun Hyung

AU - Rodriguez, Isabel

AU - Shim, Ji Heon

AU - Yasmin, Tamanna

AU - Kwak, Hee Jae

AU - Oh, Youngse

AU - Oh, Mira

AU - Lee, Kye Wan

AU - Lee, Jung Suk

AU - Kim, Do Hoon

AU - Park, Yu Hwa

AU - Moon, In Seok

AU - Choung, Se Young

AU - Jeong, Kwang Won

AU - Hong, Bin Na

AU - Kim, Seung Hyun

AU - Kang, Tong Ho

PY - 2021/1

Y1 - 2021/1

N2 - Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene and (2R,4R)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish.

AB - Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene and (2R,4R)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish.

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JO - Plants

JF - Plants

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ER -

Fatty acid derivatives isolated from the oil of persea americana (Avocado) protects against neomycin-induced hair cell damage

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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