Factors Affecting the Timing of a Central Line Associated Bloodstream Infection Onset in Children with Cancer

Mina Park, Young Mi Seo, Yoon Jung Shin, Jung Woo Han, Eunhee Cho, Hyeju Jang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Purpose: The purpose of this study is to identify controllable treatment-environment-related factors affecting the timing of a central line-associated bloodstream infection (CLABSI) onset in children with cancer with central venous catheters (CVC). Design: This study is a secondary data analysis with the data extracted from electronic medical records in a tertiary hospital in South Korea. This study was conducted by reviewing electronic medical records of 470 pediatric cancer patients younger than the age of 18 years from 2010 to 2016. Method: The timing of a CLABSI onset was identified through the onset of CLABSI and the duration of catheterization. Cox proportional hazards regression analysis was used to estimate the impact of variables on the timing of CLABSI onset. The duration of catheterization was estimated using the Kaplan–Meier method. Finding: Multivariable analysis by Cox proportional model analysis showed that there are six independent variables affecting the timing of a CLABSI onset: length of stay in hospital, catheter insertion location, use of antibiotics on day of catheter insertion, catheter function, number of blood transfusions per 100 days, and number of blood tests per 100 days. Conclusions: The findings of this study provide a foundation for the development of EBP-based CVC guidelines to effectively reduce CLABSIs and maintain a long-term CVC without a CLABSI.

Original languageEnglish
Pages (from-to)26-35
Number of pages10
JournalJournal of Pediatric Oncology Nursing
Issue number1
Publication statusPublished - 2021 Jan

Bibliographical note

Publisher Copyright:
© 2020 by Association of Pediatric Hematology/Oncology Nurses.

All Science Journal Classification (ASJC) codes

  • Pediatrics
  • Oncology(nursing)


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