TY - GEN
T1 - Facilitated self-assembly of novel dendron-based copolymers
AU - Pearson, Ryan M.
AU - Bae, Jin Woo
AU - Sunoqrot, Suhair
AU - Uddin, Sayam
AU - Hong, Seungpyo
PY - 2011
Y1 - 2011
N2 - Self-assembly of newly synthesized dendron-based amphiphilic copolymers with controlled hydrophilic-lipophilic balances has been investigated to evaluate their potential as a novel nanocarrier. The hydroxyl-terminated polyester dendron (G3) bearing a focal alkyne moiety was used to mediate the combination of poly(s-caprolactone) (PCL) with multiple polyethylene glycol (PEG) moieties. Four types of PCL-G3-mPEG with different block lengths were prepared and their structures were confirmed by 1H NMR, FT-IR, and GPC. Critical micelle concentration (CMC) values varied from 6.50 × 10 8 to 3.52 × 10 -7 M, which were lower than those reported for linear PCL-mPEG. TEM revealed that all PCL-G3-mPEG micelles were spherical with an average diameter of 20 nm. The drug release profile for each PCL-G3-mPEG was investigated by loading indomethacin (IMC), as a model drug, within the micelles. IMC was released in a controlled manner over 72 hours. Synthesized copolymers used in this study were also found to be non-cytotoxic at concentrations up to 100 M. The low CMC, along with the controlled morphology, release profile and biocompatibility, all demonstrate the potential of the dendron-based micelles as a novel nanocarrier.
AB - Self-assembly of newly synthesized dendron-based amphiphilic copolymers with controlled hydrophilic-lipophilic balances has been investigated to evaluate their potential as a novel nanocarrier. The hydroxyl-terminated polyester dendron (G3) bearing a focal alkyne moiety was used to mediate the combination of poly(s-caprolactone) (PCL) with multiple polyethylene glycol (PEG) moieties. Four types of PCL-G3-mPEG with different block lengths were prepared and their structures were confirmed by 1H NMR, FT-IR, and GPC. Critical micelle concentration (CMC) values varied from 6.50 × 10 8 to 3.52 × 10 -7 M, which were lower than those reported for linear PCL-mPEG. TEM revealed that all PCL-G3-mPEG micelles were spherical with an average diameter of 20 nm. The drug release profile for each PCL-G3-mPEG was investigated by loading indomethacin (IMC), as a model drug, within the micelles. IMC was released in a controlled manner over 72 hours. Synthesized copolymers used in this study were also found to be non-cytotoxic at concentrations up to 100 M. The low CMC, along with the controlled morphology, release profile and biocompatibility, all demonstrate the potential of the dendron-based micelles as a novel nanocarrier.
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U2 - 10.1109/IEMBS.2011.6092055
DO - 10.1109/IEMBS.2011.6092055
M3 - Conference contribution
C2 - 22256279
AN - SCOPUS:84861676313
SN - 9781424441211
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 8334
EP - 8336
BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
T2 - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Y2 - 30 August 2011 through 3 September 2011
ER -