Fabrication of levofloxacin-loaded nanofibrous scaffolds using coaxial electrospinning

Hongkwan Park; Hyunhee Yoo; Taewon Hwang; Tae Joon Park; Dong Hyun Paik; Sung Wook Choi; Jung Hyun Kim

doi:10.1007/s40005-012-0014-7

Fabrication of levofloxacin-loaded nanofibrous scaffolds using coaxial electrospinning

Hongkwan Park, Hyunhee Yoo, Taewon Hwang, Tae Joon Park, Dong Hyun Paik, Sung Wook Choi, Jung Hyun Kim

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18 Citations (Scopus)

Abstract

Levofloxacin-loaded nanofibrous scaffolds from chitosan (CS) and poly(ε-caprolactone) (PCL) were prepared using coaxial electrospinning for the controlled release of antibiotics. Levofloxacin was encapsulated in the CS phase as a core and PCL was employed to control the release of levofloxacin as a shell. The levofloxacin-loaded nanofibrous scaffolds prepared at different PCL concentrations (8, 12, 16, and 20 wt%) were characterized by SEM and TEM to confirm their surface morphology and core-shell structure. The nanofibrous scaffold prepared at a higher PCL concentration exhibited higher mechanical properties. In addition, the CS-PCL nanofibrous scaffold exhibited more sustained release of levofloxacin than PCL nanofibrous scaffolds prepared using both single and coaxial nozzles. This levofloxacin-loaded nanofibrous scaffold can potentially be employed for the sustained release of antibiotics after surgical operations.

Original language	English
Pages (from-to)	89-93
Number of pages	5
Journal	Journal of Pharmaceutical Investigation
Volume	42
Issue number	2
DOIs	https://doi.org/10.1007/s40005-012-0014-7
Publication status	Published - 2012 Apr

Bibliographical note

Funding Information:
Acknowledgements This study was financially supported by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean Government (MOST) (No. R11-2007-050-00000-0 and R01-2007-000-10353-0), the Nano R&D Program through the Korea Science and Engineering Foundation funded by the Ministry of Education, Science, and Technology (2011-0019176), the Ministry of Knowledge Economy (10030051), the Korea Science and Engineering Foundation (2010-0029220, 2009K001644), Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2011-0023064), a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A110416), and a grant from the ‘‘GRRC’’ Project of Gyeonggi Provincial Government, Korea.

All Science Journal Classification (ASJC) codes

Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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10.1007/s40005-012-0014-7

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title = "Fabrication of levofloxacin-loaded nanofibrous scaffolds using coaxial electrospinning",

abstract = "Levofloxacin-loaded nanofibrous scaffolds from chitosan (CS) and poly(ε-caprolactone) (PCL) were prepared using coaxial electrospinning for the controlled release of antibiotics. Levofloxacin was encapsulated in the CS phase as a core and PCL was employed to control the release of levofloxacin as a shell. The levofloxacin-loaded nanofibrous scaffolds prepared at different PCL concentrations (8, 12, 16, and 20 wt%) were characterized by SEM and TEM to confirm their surface morphology and core-shell structure. The nanofibrous scaffold prepared at a higher PCL concentration exhibited higher mechanical properties. In addition, the CS-PCL nanofibrous scaffold exhibited more sustained release of levofloxacin than PCL nanofibrous scaffolds prepared using both single and coaxial nozzles. This levofloxacin-loaded nanofibrous scaffold can potentially be employed for the sustained release of antibiotics after surgical operations.",

author = "Hongkwan Park and Hyunhee Yoo and Taewon Hwang and Park, {Tae Joon} and Paik, {Dong Hyun} and Choi, {Sung Wook} and Kim, {Jung Hyun}",

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AU - Choi, Sung Wook

AU - Kim, Jung Hyun

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Fabrication of levofloxacin-loaded nanofibrous scaffolds using coaxial electrospinning

Abstract

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