Extramammary Paget's disease of penis and scrotum: Diagnosis, treatment and prognosis

Won Jae Yang, Dong Suk Kim, Young Jae Im, Kang Su Cho, Koon Ho Rha, Nam Hoon Cho, Young Deuk Choi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Purpose: Penile and scrotal involvements in extramammary Paget's disease (EMPD) are exceedingly rare, with only small series or case reports having been reported in the literature. Our study was undertaken to clarify the uncertainty of the clinical outcome of this disease. Materials and methods: Between 1995 and 2003, 32 patients with penile or scrotal EMPD were treated and followed up. Local wide excision was performed in all patients, with or without an intraoperative frozen biopsy. Results: Of the 32 patients, 12 (37.5%) underwent local wide excision with an intraoperative frozen biopsy; 1 patient (8.3%) had a positive surgical margin. Conversely, 20 (62.5%) underwent local wide excision with an excessive surgical margin of upto 1 to 2cm only due to the gross findings, but 15 (75.0%) had a positive surgical margin (p<0.001). 8 of the 16 patients with a positive surgical margin had a local recurrence at the 8 month follow-up (p<0.05). One patient with invasion to the subcutaneous tissue had died of metastatic EMPD and internal malignancy (renal cell carcinoma) at the 17 month postoperative follow-up. There was no underlying adnexal carcinoma in any case. Conclusions: Local wide excision with intraoperative frozen biopsy was essential for the complete treatment of EMPD. There was no associated internal malignancy or underlying adnexal carcinoma at the initial diagnoses.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalKorean Journal of Urology
Issue number2
Publication statusPublished - 2005 Feb

All Science Journal Classification (ASJC) codes

  • Urology


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