Extracellular vesicles in kidneys and their clinical potential in renal diseases

Sul A. Lee, Chulhee Choi, Tae Hyun Yoo

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Extracellular vesicles (EVs), such as exosomes and microvesicles, are cell-derived lipid bilayer membrane particles, which deliver in-formation from host cells to recipient cells. EVs are involved in various biological processes including the modulation of the immune response, cell-to-cell communications, thrombosis, and tissue regeneration. Different types of kidney cells are known to release EVs under physiologic as well as pathologic conditions, and recent studies have found that EVs have a pathophysiologic role in different renal diseases. Given the recent advancement in EV isolation and analysis techniques, many studies have shown the diagnostic and therapeutic potential of EVs in various renal diseases, such as acute kidney injury, polycystic kidney disease, chronic kidney disease, kidney transplantation, and renal cell carcinoma. This review updates recent clinical and experimental findings on the role of EVs in renal diseases and highlights the potential clinical applicability of EVs as novel diagnostics and therapeutics.

Original languageEnglish
Pages (from-to)194-207
Number of pages14
JournalKidney Research and Clinical Practice
Volume40
Issue number2
DOIs
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 by The Korean Society of Nephrology.

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

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