Expression of sarcosine-metabolizing enzymes in thyroid cancer

Hye Min Kim, Yu Kyung Lee, Ja Seung Koo

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1 Citation (Scopus)


The purpose of this study was to investigate the expression of sarcosine metabolism-related proteins according to thyroid cancer subtypes and the implications of these findings. We performed tissue microarrays of 557 thyroid cancer cases (papillary thyroid carcinoma [PTC]: 344, follicular carcinoma [FC]: 112, medullary carcinoma [MC]: 70, poorly differentiated carcinoma [PDC]: 23, and anaplastic carcinoma [AC]: 8) and 152 follicular adenoma cases. Immunohistochemical staining for sarcosine metabolism-related molecules [glycine N-methyltransferase (GNMT), sarcosine dehydrogenase (SARDH), and l-pipecolic acid oxidase (PIPOX)] was conducted, and the results were analyzed based on clinicopathologic parameters. Results: The expression of SARDH and PIPOX was different depending on thyroid cancer subtypes. PTC showed higher expression than other subtypes (P < 0.001). Among PTC, follicular variant (FV) showed lower expression than conventional type (P = 0.010 and P < 0.001) and PTC with BRAF V600E mutation showed higher expression than PTC without BRAF V600E mutation (P < 0.001). In univariate analysis, PIPOX positivity was associated with shorter overall survival (OS) in PTC (P = 0.024). In conclusion, the expression of sarcosine metabolism-related proteins varied according to thyroid cancer subtypes. SARDH and PIPOX showed higher expression in PTC; among PTC, FVPTC showed lower expression and PTC with BRAF V600E mutation showed higher expression.

Original languageEnglish
Pages (from-to)7132-7139
Number of pages8
JournalInternational Journal of Clinical and Experimental Pathology
Issue number7
Publication statusPublished - 2016

Bibliographical note

Funding Information:
This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, and Republic of Korea (1420080). This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (2015R1A1A1A0500-1209).

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology


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