TY - JOUR
T1 - Exploring the clinical transition of engineered exosomes designed for intracellular delivery of therapeutic proteins
AU - Kim, Minseong
AU - Choi, Hojun
AU - Jang, Deok Jin
AU - Kim, Hye Jung
AU - Sub, Yujin
AU - Gee, Heon Yung
AU - Choi, Chulhee
N1 - Publisher Copyright:
© 2024 The Author(s).
PY - 2024/7
Y1 - 2024/7
N2 - Extracellular vesicles, particularly exosomes, have emerged as promising drug delivery systems owing to their unique advantages, such as biocompatibility, immune tolerability, and target specificity. Various engineering strategies have been implemented to harness these innate qualities, with a focus on enhancing the pharmacokinetic and pharmacodynamic properties of exosomes via payload loading and surface engineering for active targeting. This concise review outlines the challenges in the development of exosomes as drug carriers and offers insights into strategies for their effective clinical translation. We also highlight preclinical studies that have successfully employed anti-inflammatory exosomes and suggest future directions for exosome therapeutics. These advancements underscore the potential for integrating exosome-based therapies into clinical practice, heralding promise for future medical interventions.
AB - Extracellular vesicles, particularly exosomes, have emerged as promising drug delivery systems owing to their unique advantages, such as biocompatibility, immune tolerability, and target specificity. Various engineering strategies have been implemented to harness these innate qualities, with a focus on enhancing the pharmacokinetic and pharmacodynamic properties of exosomes via payload loading and surface engineering for active targeting. This concise review outlines the challenges in the development of exosomes as drug carriers and offers insights into strategies for their effective clinical translation. We also highlight preclinical studies that have successfully employed anti-inflammatory exosomes and suggest future directions for exosome therapeutics. These advancements underscore the potential for integrating exosome-based therapies into clinical practice, heralding promise for future medical interventions.
KW - drug delivery system
KW - exosome purification
KW - exosomes
KW - extracellular vesicles
KW - inflammation
KW - protein therapeutics
UR - http://www.scopus.com/inward/record.url?scp=85197979653&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85197979653&partnerID=8YFLogxK
U2 - 10.1093/stcltm/szae027
DO - 10.1093/stcltm/szae027
M3 - Review article
C2 - 38838263
AN - SCOPUS:85197979653
SN - 2157-6564
VL - 13
SP - 637
EP - 647
JO - Stem Cells Translational Medicine
JF - Stem Cells Translational Medicine
IS - 7
ER -