Expeditious synthesis of indolizine derivatives via iodine mediated 5-endo-dig cyclization

Ikyon Kim; Jihyun Choi; Hye Kyoung Won; Ge Hyeoung Lee

doi:10.1016/j.tetlet.2007.07.180

Expeditious synthesis of indolizine derivatives via iodine mediated 5-endo-dig cyclization

Ikyon Kim, Jihyun Choi, Hye Kyoung Won, Ge Hyeoung Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

Iodine-mediated 5-endo-dig cyclization of propargylic esters 2 at room temperature proceeded smoothly to give highly functionalized indolizines 3 in excellent yields. A pyridine group was employed as a nucleophilic partner in this facile process for the first time.

Original language	English
Pages (from-to)	6863-6867
Number of pages	5
Journal	Tetrahedron Letters
Volume	48
Issue number	39
DOIs	https://doi.org/10.1016/j.tetlet.2007.07.180
Publication status	Published - 2007 Sept 24

Bibliographical note

Funding Information:
We thank the Center for Biological Modulators and Korea Research Institute of Chemical Technology for generous financial support.

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2007.07.180

Cite this

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title = "Expeditious synthesis of indolizine derivatives via iodine mediated 5-endo-dig cyclization",

abstract = "Iodine-mediated 5-endo-dig cyclization of propargylic esters 2 at room temperature proceeded smoothly to give highly functionalized indolizines 3 in excellent yields. A pyridine group was employed as a nucleophilic partner in this facile process for the first time.",

author = "Ikyon Kim and Jihyun Choi and Won, {Hye Kyoung} and Lee, {Ge Hyeoung}",

note = "Funding Information: We thank the Center for Biological Modulators and Korea Research Institute of Chemical Technology for generous financial support. ",

year = "2007",

month = sep,

day = "24",

doi = "10.1016/j.tetlet.2007.07.180",

language = "English",

volume = "48",

pages = "6863--6867",

journal = "Tetrahedron Letters",

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T1 - Expeditious synthesis of indolizine derivatives via iodine mediated 5-endo-dig cyclization

AU - Kim, Ikyon

AU - Choi, Jihyun

AU - Won, Hye Kyoung

AU - Lee, Ge Hyeoung

N1 - Funding Information: We thank the Center for Biological Modulators and Korea Research Institute of Chemical Technology for generous financial support.

PY - 2007/9/24

Y1 - 2007/9/24

N2 - Iodine-mediated 5-endo-dig cyclization of propargylic esters 2 at room temperature proceeded smoothly to give highly functionalized indolizines 3 in excellent yields. A pyridine group was employed as a nucleophilic partner in this facile process for the first time.

AB - Iodine-mediated 5-endo-dig cyclization of propargylic esters 2 at room temperature proceeded smoothly to give highly functionalized indolizines 3 in excellent yields. A pyridine group was employed as a nucleophilic partner in this facile process for the first time.

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U2 - 10.1016/j.tetlet.2007.07.180

DO - 10.1016/j.tetlet.2007.07.180

M3 - Article

AN - SCOPUS:34548209269

SN - 0040-4039

VL - 48

SP - 6863

EP - 6867

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 39

ER -

Expeditious synthesis of indolizine derivatives via iodine mediated 5-endo-dig cyclization

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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