Exercise-induced beige adipogenesis of iWAT in Cidea reporter mice

Jin Kyung Kim, Hye Sun Go, Sol Pin Kim, Il Yong Kim, Yun Hee Lee, Seung Hyun Oh, Ho Lee, Je Kyung Seong

Research output: Contribution to journalArticlepeer-review

Abstract

Obesity is caused by an imbalance between energy intake and energy expenditure. Exercise is attracting attention as one of the ways to treat obesity. Exercise induces ‘beige adipogenesis' in white adipose tissue, increasing total energy expenditure via energy dissipation in the form of heat. Also, beige adipogenesis can be induced by treatment with a beta-adrenergic receptor agonist. We developed a Cidea-dual reporter mouse (Cidea-P2A-Luc2-T2A-tdTomato, Luciferase/tdTomato) model to trace and measure beige adipogenesis in vivo. As a result, both exercise and injection of beta-adrenergic receptor agonist induced beige adipogenesis and was detected through fluorescence and luminescence. We confirmed that exercise and beta-adrenergic receptor agonist induce beige adipogenesis in Cidea-dual reporter mouse, which will be widely used for detecting beige adipogenesis in vivo.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalBMB reports
Volume55
Issue number4
DOIs
Publication statusPublished - 2022

Bibliographical note

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© 2022. All Rights Reserved.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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