Exacerbation of Avellino corneal dystrophy after LASIK in North America

Christopher S. Banning; Woon Cho Kim; J. Bradley Randleman; Eung Kweon Kim; R. Doyle Stulting

doi:10.1097/01.ico.0000195949.93695.37

Exacerbation of Avellino corneal dystrophy after LASIK in North America

Christopher S. Banning, Woon Cho Kim, J. Bradley Randleman, Eung Kweon Kim, R. Doyle Stulting

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

PURPOSE: To report the first case of Avellino corneal dystrophy exacerbation after LASIK in a white or North American patient. METHODS: Case report and literature review. RESULTS: A 25-year-old white female developed progressive corneal opacities after LASIK. Preoperative examination had revealed only subtle white corneal opacities in each eye. The patient's mother had similar corneal opacities. DNA analysis of the patient revealed a heterozygous mutation at the R124H location in the BIGH3 gene. CONCLUSIONS: LASIK can exacerbate Avellino corneal dystrophy and should be avoided in patients with this condition. A careful history and genetic analysis can identify affected patients and those at risk.

Original language	English
Pages (from-to)	482-484
Number of pages	3
Journal	Cornea
Volume	25
Issue number	4
DOIs	https://doi.org/10.1097/01.ico.0000195949.93695.37
Publication status	Published - 2006 May

All Science Journal Classification (ASJC) codes

Ophthalmology

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10.1097/01.ico.0000195949.93695.37

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title = "Exacerbation of Avellino corneal dystrophy after LASIK in North America",

abstract = "PURPOSE: To report the first case of Avellino corneal dystrophy exacerbation after LASIK in a white or North American patient. METHODS: Case report and literature review. RESULTS: A 25-year-old white female developed progressive corneal opacities after LASIK. Preoperative examination had revealed only subtle white corneal opacities in each eye. The patient's mother had similar corneal opacities. DNA analysis of the patient revealed a heterozygous mutation at the R124H location in the BIGH3 gene. CONCLUSIONS: LASIK can exacerbate Avellino corneal dystrophy and should be avoided in patients with this condition. A careful history and genetic analysis can identify affected patients and those at risk.",

author = "Banning, {Christopher S.} and Kim, {Woon Cho} and Randleman, {J. Bradley} and Kim, {Eung Kweon} and Stulting, {R. Doyle}",

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T1 - Exacerbation of Avellino corneal dystrophy after LASIK in North America

AU - Banning, Christopher S.

AU - Kim, Woon Cho

AU - Randleman, J. Bradley

AU - Kim, Eung Kweon

AU - Stulting, R. Doyle

PY - 2006/5

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N2 - PURPOSE: To report the first case of Avellino corneal dystrophy exacerbation after LASIK in a white or North American patient. METHODS: Case report and literature review. RESULTS: A 25-year-old white female developed progressive corneal opacities after LASIK. Preoperative examination had revealed only subtle white corneal opacities in each eye. The patient's mother had similar corneal opacities. DNA analysis of the patient revealed a heterozygous mutation at the R124H location in the BIGH3 gene. CONCLUSIONS: LASIK can exacerbate Avellino corneal dystrophy and should be avoided in patients with this condition. A careful history and genetic analysis can identify affected patients and those at risk.

AB - PURPOSE: To report the first case of Avellino corneal dystrophy exacerbation after LASIK in a white or North American patient. METHODS: Case report and literature review. RESULTS: A 25-year-old white female developed progressive corneal opacities after LASIK. Preoperative examination had revealed only subtle white corneal opacities in each eye. The patient's mother had similar corneal opacities. DNA analysis of the patient revealed a heterozygous mutation at the R124H location in the BIGH3 gene. CONCLUSIONS: LASIK can exacerbate Avellino corneal dystrophy and should be avoided in patients with this condition. A careful history and genetic analysis can identify affected patients and those at risk.

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Exacerbation of Avellino corneal dystrophy after LASIK in North America

Abstract

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