Estrogen release from metallic stent surface for the prevention of restenosis

Yoon Ki Joung, Hyun Il Kim, Sung Soo Kim, Kwang Hoe Chung, Yang Soo Jang, Ki Dong Park

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11 Citations (Scopus)


For the prevention of coronary restenosis, estrogen was coupled onto a metallic stent and in vitro release of estrogen was investigated. Estrogen was introduced to the metal surface using a hydrolysable covalent bond for local sustained delivery of drug as follows: (i) the stainless steel (SS) surface was activated with silane by plasma polymerization, (ii) the activated surface (SS-Si surface) was treated with acrylic acid by plasma polymerization (SS-Si-AAc surface), and (iii) 17β-estradiol (E2) was covalently linked to the carboxyl group on that surface (SS-Si-AAc-E 2 surface). The modified surfaces were characterized by X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FT-IR) spectroscopy, and water contact angle measurement. The amount of E2 was measured by UV-visible spectrophotometry and high performance liquid chromatography (HPLC). The in vitro release profile of E2 demonstrated sustained release of E2 in aqueous buffer. In summary, a novel method of immobilizing estrogen onto a metallic stent surface using plasma polymerization has been developed. The obtained results attest to the usefulness of the estrogen-releasing stent for preventing restenosis.

Original languageEnglish
Pages (from-to)83-91
Number of pages9
JournalJournal of Controlled Release
Issue number1-2
Publication statusPublished - 2003 Sept 19

Bibliographical note

Funding Information:
This work was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV11-0002).

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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