Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic variant LMNA p.Asp364His

Jaewon Oh, Sun Ho Lee, Jungyoon Choi, Jong Rak Choi, Sangwoo Kim, Yun Ji Cha, Hyo Kyoung Choi, Dongju Won, Ho Geun Yoon, Sahng Wook Park, Seok Min Kang, Seung Tae Lee, Seung Hyun Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Cardiac laminopathy caused by mutations in the LMNA gene are common and highly penetrant with a poor prognosis. We have generated a novel human induced pluripotent stem cell(iPSC) lines YCMi003-A from a patient with dilated cardiomyopathy associated with genetic variant LMNA c.1090G > C; p.Asp364His. We reprogrammed patient-specific peripheral blood mononuclear cells using five episomal vectors Oct4, Sox2, Lin28, L-Myc, and Klf4. The reported iPSC line would be a useful model for in vitro modeling of cardiac laminopathy.

Original languageEnglish
Article number102508
JournalStem Cell Research
Volume56
DOIs
Publication statusPublished - 2021 Oct

Bibliographical note

Publisher Copyright:
© 2021 The Author(s)

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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