Epigallocatechin gallate (Egcg), a green tea polyphenol, reduces coronavirus replication in a mouse model

Rackhyun Park; Minsu Jang; Yea In Park; Yeonjeong Park; Woochul Jung; Jayhyun Park; Junsoo Park

doi:10.3390/v13122533

Epigallocatechin gallate (Egcg), a green tea polyphenol, reduces coronavirus replication in a mouse model

Rackhyun Park, Minsu Jang, Yea In Park, Yeonjeong Park, Woochul Jung, Jayhyun Park, Junsoo Park

Division of Bioscience and Biotechnology

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The COVID-19 pandemic has resulted in a huge number of deaths from 2020 to 2021; however, effective antiviral drugs against SARS-CoV-2 are currently under development. Recent studies have demonstrated that green tea polyphenols, particularly EGCG, inhibit coronavirus enzymes as well as coronavirus replication in vitro. Herein, we examined the inhibitory effect of green tea polyphenols on coronavirus replication in a mouse model. We used epigallocatechin gallate (EGCG) and green tea polyphenols containing more than 60% catechin (GTP60) and human coronavirus OC43 (HCoV-OC43) as a surrogate for SARS-CoV-2. Scanning electron microscopy analysis results showed that HCoV-OC43 infection resulted in virion particle production in infected cells. EGCG and GTP60 treatment reduced coronavirus protein and virus production in the cells. Finally, EGCG-and GTP60-fed mice exhibited reduced levels of coronavirus RNA in mouse lungs. These results demonstrate that green tea polyphenol treatment is effective in decreasing the level of coronavirus in vivo.

Original language	English
Article number	2533
Journal	Viruses
Volume	13
Issue number	12
DOIs	https://doi.org/10.3390/v13122533
Publication status	Published - 2021 Dec

Bibliographical note

Funding Information:
Funding: This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (2019R1A2C1006511).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "The COVID-19 pandemic has resulted in a huge number of deaths from 2020 to 2021; however, effective antiviral drugs against SARS-CoV-2 are currently under development. Recent studies have demonstrated that green tea polyphenols, particularly EGCG, inhibit coronavirus enzymes as well as coronavirus replication in vitro. Herein, we examined the inhibitory effect of green tea polyphenols on coronavirus replication in a mouse model. We used epigallocatechin gallate (EGCG) and green tea polyphenols containing more than 60% catechin (GTP60) and human coronavirus OC43 (HCoV-OC43) as a surrogate for SARS-CoV-2. Scanning electron microscopy analysis results showed that HCoV-OC43 infection resulted in virion particle production in infected cells. EGCG and GTP60 treatment reduced coronavirus protein and virus production in the cells. Finally, EGCG-and GTP60-fed mice exhibited reduced levels of coronavirus RNA in mouse lungs. These results demonstrate that green tea polyphenol treatment is effective in decreasing the level of coronavirus in vivo.",

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AU - Jung, Woochul

AU - Park, Jayhyun

AU - Park, Junsoo

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Epigallocatechin gallate (Egcg), a green tea polyphenol, reduces coronavirus replication in a mouse model

Abstract

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