Epidemiological features and economic burden of guillain-barré syndrome in south korea: A nationwide population-based study

Ah Young Kim, Hankil Lee, Young Mock Lee, Hye Young Kang

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8 Citations (Scopus)


Background and Purpose Guillain-Barré syndrome (GBS) is rare, but its symptoms are severe and they occasionally lead to long-term disability. Country-specific epidemiological evidence is useful for detecting potential problems at the population level. This study investigated the epidemiological and economic characteristics of GBS in South Korea. Methods The Korean National Health Insurance Service claims data from 2010 to 2016 were used to identify incident cases as newly hospitalized patients with a primary diagnosis of GBS (the 10th revision of the International Classification Disease code of G61.0). New cases were defined as patients not having claim records for GBS within one year prior to the hospital admission for GBS. Results The incidence rate increased by 45.6% between 2010 and 2016, from 1.28 to 1.82 per 100,000 population. All age groups other than <20 years showed increasing trends. The incidence rate was highest in those aged 65 years to 74 years. Approximately 72% of the incident GBS cases had antecedent infection within 42 days before GBS was diagnosed. Children younger than 10 years constituted the highest proportion of antecedent infections (93.7%). The average length of stay per GBS hospitalization was 33.5 days. Patients had an average of 7.48 outpatient visits for GBS treatment per year. The economic burden from a societal perspective of treating GBS during the first year was USD 16,428. Conclusions The increasing incidence trend and substantial economic burden of GBS strongly advocate the development of effective strategies for preventing and managing GBS.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalJournal of Clinical Neurology (Korea)
Issue number2
Publication statusPublished - 2021 Apr

Bibliographical note

Funding Information:
This work was supported in part by a grant from Korea Centers for Disease Control & Prevention (grant number 2018-E2402-00). The funding source had no involvement in the study design; the collection, analysis and interpretation of data; the writing of the report; or the decision to submit the article for publication.

Publisher Copyright:
© 2021 Korean Neurological Association.

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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