Environmental risk factors, protective factors, and biomarkers for postpartum depressive symptoms: an umbrella review

Jae Han Kim, Jong Yeob Kim, Seul Lee, San Lee, Brendon Stubbs, Ai Koyanagi, Elena Dragioti, Louis Jacob, Andre F. Carvalho, Joaquim Radua, Trevor Thompson, Lee Smith, Hans Oh, Lin Yang, Michele Fornaro, Andrew Stickley, Gonzalo Salazar de Pablo, Kalthoum Tizaoui, Dong Keon Yon, Seung Won LeeJimin Hwang, Jae Il Shin, Paolo Fusar-Poli

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

We performed an umbrella review on environmental risk/protective factors and biomarkers for postpartum depressive symptoms to establish a hierarchy of evidence. We systematically searched PubMed, Embase, and the Cochrane Database of Systematic Reviews from inception until 12 January 2021. We included systematic reviews providing meta-analyses related to our research objectives. Methodological quality was assessed by AMSTAR 2, and the certainty of evidence was evaluated by GRADE. This review was registered in PROSPERO (CRD42021230784). We identified 30 articles, which included 45 environmental risk/protective factors (154,594 cases, 7,302,273 population) and 9 biomarkers (2018 cases, 16,757 population). The credibility of evidence was convincing (class I) for antenatal anxiety (OR 2.49, 1.91–3.25) and psychological violence (OR 1.93, 1.54–2.42); and highly suggestive (class II) for intimate partner violence experience (OR 2.86, 2.12–3.87), intimate partner violence during pregnancy (RR 2.81, 2.11–3.74), smoking during pregnancy (OR 2.39, 1.78–3.2), history of premenstrual syndrome (OR 2.2, 1.81–2.68), any type of violence experience (OR 2.04, 1.72–2.41), primiparity compared to multiparity (RR 1.76, 1.59–1.96), and unintended pregnancy (OR 1.53, 1.35–1.75).

Original languageEnglish
Article number104761
JournalNeuroscience and Biobehavioral Reviews
Volume140
DOIs
Publication statusPublished - 2022 Sept

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Ltd

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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