Enhancement of oxidative response and cytokine production by yam mucopolysaccharide in murine peritoneal macrophage

Eun Mi Choi; Jae Kwan Hwang

doi:10.1016/S0367-326X(02)00238-1

Enhancement of oxidative response and cytokine production by yam mucopolysaccharide in murine peritoneal macrophage

Eun Mi Choi, Jae Kwan Hwang

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Yam (Dioscorea batatas) mucopolysaccharide (YMP) was examined for the ability to induce secretory and cellular responses in murine peritoneal macrophages. When macrophages were treated with various doses (10-100 μg/ml) of YMP for 48 h, a significant cytotoxicity against B 16 cells was observed. YMP also increased the myeloperoxidase activity and the production of H₂O₂, O₂^-, nitric oxide (NO) and tumor necrosis factor (TNF-α). However, there was a little alteration on the production of IFN-γ. These results indicate that reactive oxygen intermediates (ROI), reactive nitrogen intermediates (RNI) and TNF-α are likely major mediators of cytotoxic activity of YMP-treated macrophages.

Original language	English
Pages (from-to)	629-637
Number of pages	9
Journal	Fitoterapia
Volume	73
Issue number	7-8
DOIs	https://doi.org/10.1016/S0367-326X(02)00238-1
Publication status	Published - 2002 Dec

Bibliographical note

Funding Information:
This work was supported by the National Research Lab program through Functional Biopolymer Lab at Yonsei University (2000-N-NL-01-C-299).

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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10.1016/S0367-326X(02)00238-1

Cite this

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title = "Enhancement of oxidative response and cytokine production by yam mucopolysaccharide in murine peritoneal macrophage",

abstract = "Yam (Dioscorea batatas) mucopolysaccharide (YMP) was examined for the ability to induce secretory and cellular responses in murine peritoneal macrophages. When macrophages were treated with various doses (10-100 μg/ml) of YMP for 48 h, a significant cytotoxicity against B 16 cells was observed. YMP also increased the myeloperoxidase activity and the production of H2O2, O2-, nitric oxide (NO) and tumor necrosis factor (TNF-α). However, there was a little alteration on the production of IFN-γ. These results indicate that reactive oxygen intermediates (ROI), reactive nitrogen intermediates (RNI) and TNF-α are likely major mediators of cytotoxic activity of YMP-treated macrophages.",

author = "Choi, {Eun Mi} and Hwang, {Jae Kwan}",

note = "Funding Information: This work was supported by the National Research Lab program through Functional Biopolymer Lab at Yonsei University (2000-N-NL-01-C-299).",

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language = "English",

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T1 - Enhancement of oxidative response and cytokine production by yam mucopolysaccharide in murine peritoneal macrophage

AU - Choi, Eun Mi

AU - Hwang, Jae Kwan

N1 - Funding Information: This work was supported by the National Research Lab program through Functional Biopolymer Lab at Yonsei University (2000-N-NL-01-C-299).

PY - 2002/12

Y1 - 2002/12

N2 - Yam (Dioscorea batatas) mucopolysaccharide (YMP) was examined for the ability to induce secretory and cellular responses in murine peritoneal macrophages. When macrophages were treated with various doses (10-100 μg/ml) of YMP for 48 h, a significant cytotoxicity against B 16 cells was observed. YMP also increased the myeloperoxidase activity and the production of H2O2, O2-, nitric oxide (NO) and tumor necrosis factor (TNF-α). However, there was a little alteration on the production of IFN-γ. These results indicate that reactive oxygen intermediates (ROI), reactive nitrogen intermediates (RNI) and TNF-α are likely major mediators of cytotoxic activity of YMP-treated macrophages.

AB - Yam (Dioscorea batatas) mucopolysaccharide (YMP) was examined for the ability to induce secretory and cellular responses in murine peritoneal macrophages. When macrophages were treated with various doses (10-100 μg/ml) of YMP for 48 h, a significant cytotoxicity against B 16 cells was observed. YMP also increased the myeloperoxidase activity and the production of H2O2, O2-, nitric oxide (NO) and tumor necrosis factor (TNF-α). However, there was a little alteration on the production of IFN-γ. These results indicate that reactive oxygen intermediates (ROI), reactive nitrogen intermediates (RNI) and TNF-α are likely major mediators of cytotoxic activity of YMP-treated macrophages.

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Enhancement of oxidative response and cytokine production by yam mucopolysaccharide in murine peritoneal macrophage

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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