Enhancement of human mesenchymal stem cell infiltration into the electrospun poly(lactic-co-glycolic acid) scaffold by fluid shear stress

Min Sung Kim; Mi Hee Lee; Byeong Ju Kwon; Min Ah Koo; Gyeung Mi Seon; Jong Chul Park

doi:10.1016/j.bbrc.2015.05.048

Enhancement of human mesenchymal stem cell infiltration into the electrospun poly(lactic-co-glycolic acid) scaffold by fluid shear stress

Min Sung Kim, Mi Hee Lee, Byeong Ju Kwon, Min Ah Koo, Gyeung Mi Seon, Jong Chul Park

Department of Medical Engineering

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The infiltration of the cells into the scaffolds is important phenomenon to give them good biocompatibility and even biodegradability. Fluid shear stress is one of the candidates for the infiltration of cells into scaffolds. Here we investigated the directional migration of human mesenchymal stem cells and infiltration into PLGA scaffold by fluid shear stress. The human mesenchymal stem cells showed directional migrations following the direction of the flow (8, 16 dyne/cm²). In the scaffold models, the fluid shear stress (8 dyne/cm²) enhanced the infiltration of cells but did not influence on the infiltration of Poly(lactic-co-glycolic acid) particles.

Original language	English
Pages (from-to)	137-142
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	463
Issue number	1-2
DOIs	https://doi.org/10.1016/j.bbrc.2015.05.048
Publication status	Published - 2015

Bibliographical note

Funding Information:
This research was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health & Welfare, Republic of Korea (A 120878).

Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2015.05.048

Cite this

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title = "Enhancement of human mesenchymal stem cell infiltration into the electrospun poly(lactic-co-glycolic acid) scaffold by fluid shear stress",

abstract = "The infiltration of the cells into the scaffolds is important phenomenon to give them good biocompatibility and even biodegradability. Fluid shear stress is one of the candidates for the infiltration of cells into scaffolds. Here we investigated the directional migration of human mesenchymal stem cells and infiltration into PLGA scaffold by fluid shear stress. The human mesenchymal stem cells showed directional migrations following the direction of the flow (8, 16 dyne/cm2). In the scaffold models, the fluid shear stress (8 dyne/cm2) enhanced the infiltration of cells but did not influence on the infiltration of Poly(lactic-co-glycolic acid) particles.",

author = "Kim, {Min Sung} and Lee, {Mi Hee} and Kwon, {Byeong Ju} and Koo, {Min Ah} and Seon, {Gyeung Mi} and Park, {Jong Chul}",

note = "Funding Information: This research was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health & Welfare, Republic of Korea (A 120878). Publisher Copyright: {\textcopyright} 2015 Elsevier Inc. All rights reserved.",

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AU - Lee, Mi Hee

AU - Kwon, Byeong Ju

AU - Koo, Min Ah

AU - Seon, Gyeung Mi

AU - Park, Jong Chul

N1 - Funding Information: This research was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health & Welfare, Republic of Korea (A 120878). Publisher Copyright: © 2015 Elsevier Inc. All rights reserved.

PY - 2015

Y1 - 2015

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AB - The infiltration of the cells into the scaffolds is important phenomenon to give them good biocompatibility and even biodegradability. Fluid shear stress is one of the candidates for the infiltration of cells into scaffolds. Here we investigated the directional migration of human mesenchymal stem cells and infiltration into PLGA scaffold by fluid shear stress. The human mesenchymal stem cells showed directional migrations following the direction of the flow (8, 16 dyne/cm2). In the scaffold models, the fluid shear stress (8 dyne/cm2) enhanced the infiltration of cells but did not influence on the infiltration of Poly(lactic-co-glycolic acid) particles.

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Enhancement of human mesenchymal stem cell infiltration into the electrospun poly(lactic-co-glycolic acid) scaffold by fluid shear stress

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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