Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles

Jin Kim; Kisuk Yang; Jong Seung Lee; Yong Hwa Hwang; Hyun Ji Park; Kook In Park; Dong Yun Lee; Seung Woo Cho

doi:10.1002/mabi.201600540

Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles

Jin Kim, Kisuk Yang, Jong Seung Lee, Yong Hwa Hwang, Hyun Ji Park, Kook In Park, Dong Yun Lee, Seung Woo Cho

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Graphene oxide (GO) has received increasing attention in bioengineering fields due to its unique biophysical and electrical properties, along with excellent biocompatibility. The application of GO nanoparticles (GO-NPs) to engineer self-renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. GO-NPs added to hfNSC culture during neurosphere formation substantially promote cell-to-cell and cell-to-matrix interactions in neurospheres. Accordingly, GO-NP-treated hfNSCs show enhanced self-renewal ability and accelerated differentiation compared to untreated cells, indicating the utility of GO in developing stem cell therapies for neurogenesis. (Figure presented.).

Original language	English
Article number	1600540
Journal	Macromolecular Bioscience
Volume	17
Issue number	8
DOIs	https://doi.org/10.1002/mabi.201600540
Publication status	Published - 2017 Aug

Bibliographical note

Funding Information:
This work was supported by National Research Foundation of Korea (NRF) grants (NRF-2015R1A2A1A15053771, NRF-2015M3A9B4071076, and NRF-2015R1A2A1A05001832). J.K. is a fellowship awardee of the Global Ph.D. Fellowship program (NRF-2013-Global Ph.D. Fellowship Program).

Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

Access to Document

10.1002/mabi.201600540

Cite this

@article{83ebd2ac255b494987d8d000e496c53b,

title = "Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles",

abstract = "Graphene oxide (GO) has received increasing attention in bioengineering fields due to its unique biophysical and electrical properties, along with excellent biocompatibility. The application of GO nanoparticles (GO-NPs) to engineer self-renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. GO-NPs added to hfNSC culture during neurosphere formation substantially promote cell-to-cell and cell-to-matrix interactions in neurospheres. Accordingly, GO-NP-treated hfNSCs show enhanced self-renewal ability and accelerated differentiation compared to untreated cells, indicating the utility of GO in developing stem cell therapies for neurogenesis. (Figure presented.).",

author = "Jin Kim and Kisuk Yang and Lee, {Jong Seung} and Hwang, {Yong Hwa} and Park, {Hyun Ji} and Park, {Kook In} and Lee, {Dong Yun} and Cho, {Seung Woo}",

note = "Funding Information: This work was supported by National Research Foundation of Korea (NRF) grants (NRF-2015R1A2A1A15053771, NRF-2015M3A9B4071076, and NRF-2015R1A2A1A05001832). J.K. is a fellowship awardee of the Global Ph.D. Fellowship program (NRF-2013-Global Ph.D. Fellowship Program). Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2017",

month = aug,

doi = "10.1002/mabi.201600540",

language = "English",

volume = "17",

journal = "Macromolecular Bioscience",

issn = "1616-5187",

publisher = "Wiley-VCH Verlag",

number = "8",

}

TY - JOUR

T1 - Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles

AU - Kim, Jin

AU - Yang, Kisuk

AU - Lee, Jong Seung

AU - Hwang, Yong Hwa

AU - Park, Hyun Ji

AU - Park, Kook In

AU - Lee, Dong Yun

AU - Cho, Seung Woo

N1 - Funding Information: This work was supported by National Research Foundation of Korea (NRF) grants (NRF-2015R1A2A1A15053771, NRF-2015M3A9B4071076, and NRF-2015R1A2A1A05001832). J.K. is a fellowship awardee of the Global Ph.D. Fellowship program (NRF-2013-Global Ph.D. Fellowship Program). Publisher Copyright: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2017/8

Y1 - 2017/8

N2 - Graphene oxide (GO) has received increasing attention in bioengineering fields due to its unique biophysical and electrical properties, along with excellent biocompatibility. The application of GO nanoparticles (GO-NPs) to engineer self-renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. GO-NPs added to hfNSC culture during neurosphere formation substantially promote cell-to-cell and cell-to-matrix interactions in neurospheres. Accordingly, GO-NP-treated hfNSCs show enhanced self-renewal ability and accelerated differentiation compared to untreated cells, indicating the utility of GO in developing stem cell therapies for neurogenesis. (Figure presented.).

AB - Graphene oxide (GO) has received increasing attention in bioengineering fields due to its unique biophysical and electrical properties, along with excellent biocompatibility. The application of GO nanoparticles (GO-NPs) to engineer self-renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. GO-NPs added to hfNSC culture during neurosphere formation substantially promote cell-to-cell and cell-to-matrix interactions in neurospheres. Accordingly, GO-NP-treated hfNSCs show enhanced self-renewal ability and accelerated differentiation compared to untreated cells, indicating the utility of GO in developing stem cell therapies for neurogenesis. (Figure presented.).

UR - http://www.scopus.com/inward/record.url?scp=85017585532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017585532&partnerID=8YFLogxK

U2 - 10.1002/mabi.201600540

DO - 10.1002/mabi.201600540

M3 - Article

C2 - 28394476

AN - SCOPUS:85017585532

SN - 1616-5187

VL - 17

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

IS - 8

M1 - 1600540

ER -

Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this