Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination

Sang Jun Ha; Su Hyung Park; Hye Ju Kim; Seung Chul Kim; Hyang Ju Kang; Eun Gae Lee; Soon Geon Kwon; Byong Moon Kim; Sung Hee Lee; Won Bae Kim; Young Chul Sung; Sang Nae Cho

doi:10.1128/IAI.01781-05

Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination

Sang Jun Ha, Su Hyung Park, Hye Ju Kim, Seung Chul Kim, Hyang Ju Kang, Eun Gae Lee, Soon Geon Kwon, Byong Moon Kim, Sung Hee Lee, Won Bae Kim, Young Chul Sung, Sang Nae Cho

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection against Mycobacterium tuberculosis.

Original language	English
Pages (from-to)	4954-4959
Number of pages	6
Journal	Infection and Immunity
Volume	74
Issue number	8
DOIs	https://doi.org/10.1128/IAI.01781-05
Publication status	Published - 2006 Aug

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/IAI.01781-05

Cite this

Ha, S. J., Park, S. H., Kim, H. J., Kim, S. C., Kang, H. J., Lee, E. G., Kwon, S. G., Kim, B. M., Lee, S. H., Kim, W. B., Sung, Y. C., & Cho, S. N. (2006). Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination. Infection and Immunity, 74(8), 4954-4959. https://doi.org/10.1128/IAI.01781-05

@article{ef86117b41b9457f9f8f6bdf9c859229,

title = "Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination",

abstract = "Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection against Mycobacterium tuberculosis.",

author = "Ha, {Sang Jun} and Park, {Su Hyung} and Kim, {Hye Ju} and Kim, {Seung Chul} and Kang, {Hyang Ju} and Lee, {Eun Gae} and Kwon, {Soon Geon} and Kim, {Byong Moon} and Lee, {Sung Hee} and Kim, {Won Bae} and Sung, {Young Chul} and Cho, {Sang Nae}",

year = "2006",

month = aug,

doi = "10.1128/IAI.01781-05",

language = "English",

volume = "74",

pages = "4954--4959",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "8",

}

TY - JOUR

T1 - Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination

AU - Ha, Sang Jun

AU - Park, Su Hyung

AU - Kim, Hye Ju

AU - Kim, Seung Chul

AU - Kang, Hyang Ju

AU - Lee, Eun Gae

AU - Kwon, Soon Geon

AU - Kim, Byong Moon

AU - Lee, Sung Hee

AU - Kim, Won Bae

AU - Sung, Young Chul

AU - Cho, Sang Nae

PY - 2006/8

Y1 - 2006/8

N2 - Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection against Mycobacterium tuberculosis.

AB - Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection against Mycobacterium tuberculosis.

UR - http://www.scopus.com/inward/record.url?scp=33746592081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746592081&partnerID=8YFLogxK

U2 - 10.1128/IAI.01781-05

DO - 10.1128/IAI.01781-05

M3 - Article

C2 - 16861689

AN - SCOPUS:33746592081

SN - 0019-9567

VL - 74

SP - 4954

EP - 4959

JO - Infection and Immunity

JF - Infection and Immunity

IS - 8

ER -

Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this