Enhanced detection of virus particles by nanoisland-based localized surface plasmon resonance

Hojeong Yu, Kyujung Kim, Kyungjae Ma, Wonju Lee, Joung Woo Choi, Chae Ok Yun, Donghyun Kim

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)


In this paper, we investigate localized surface plasmon resonance (SPR) detection based on nanoislands. Theoretical calculation performed with rigorous coupled-wave analysis and analytical transfer matrix method using effective medium theory suggests improvement on nanoislands in the limit of detection and sensitivity over conventional thin film-based SPR detection. Experimental results obtained with non-specific detection of ambient adenovirus confirm the improvement by more than one order of magnitude increase in the limit of detection. The enhancement achieved with nanoislands was explored in connection with efficient overlap between target and near-field distribution produced by nanoislands.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalBiosensors and Bioelectronics
Issue number1
Publication statusPublished - 2013 Mar 15

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation (NRF) grants funded by the Korean Government ( 2009–0070732 , 2010-0007993 , and 2011-0017500 ). We thank Young Wook Chang, Ju-Hyoung Kim and Kyung-Hwa Yoo of Department of Physics at Yonsei University for AFM measurements of nanoisland samples.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


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