Engineering biomaterial systems to enhance viral vector gene delivery

Jae Hyung Jang, David V. Schaffer, Lonnie D. Shea

Research output: Contribution to journalReview articlepeer-review

100 Citations (Scopus)


Integrating viral gene delivery with engineered biomaterials is a promising strategy to overcome a number of challenges associated with virus-mediated gene delivery, including inefficient delivery to specific cell types, limited tropism, spread of vectors to distant sites, and immune responses. Viral vectors can be combined with biomaterials either through encapsulation within the material or immobilization onto a material surface. Subsequent biomaterial-based delivery can increase the vector's residence time within the target site, thereby potentially providing localized delivery, enhancing transduction, and extending the duration of gene expression. Alternatively, physical or chemical modification of viral vectors with biomaterials can be employed to modulate the tropism of viruses or reduce inflammatory and immune responses, both of which may benefit transduction. This review describes strategies to promote viral gene delivery technologies using biomaterials, potentially providing opportunities for numerous applications of gene therapy to inherited or acquired disorders, infectious disease, and regenerative medicine.

Original languageEnglish
Pages (from-to)1407-1415
Number of pages9
JournalMolecular Therapy
Issue number8
Publication statusPublished - 2011 Aug

Bibliographical note

Funding Information:
We acknowledge support from the National Research Foundation (NRF) grant funded by the Korea government (MEST) through the Active Polymer Center for Pattern Integration (No. R11-2007-050-00000-0) and the Seoul R&BD Program (10816). We also acknowledge funding from NIH (R01HL081527, RO1EB005678).

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery


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