Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem

Hyun Woo Park; Si Young Cho; Hyun Hee Kim; Bong Sik Yun; Jeong Un Kim; Sang Jun Lee; Jiyong Park

doi:10.1016/j.bmcl.2014.11.045

Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem

Hyun Woo Park, Si Young Cho, Hyun Hee Kim, Bong Sik Yun, Jeong Un Kim, Sang Jun Lee, Jiyong Park

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Syringaresinol exists either exclusively as one enantiomer or enantiomeric mixtures in plant foods. We found that (+)-syringaresinol, but not (-)-syringaresinol, upregulates silent information regulator two ortholog 1 (SIRT1) gene expression, and thus, Panax ginseng berry with predominantly high contents of (+)-syringaresinol exhibits higher activity in inducing SIRT1 gene expression than Acanthopanax senticosus Harms stem with almost equal proportion of the two enantiomers. These findings highlight the importance of the absolute configuration of syringaresinol for the biological activity.

Original language	English
Pages (from-to)	307-309
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2014.11.045
Publication status	Published - 2015 Jan 15

Bibliographical note

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© 2014 Elsevier Ltd. All rights reserved.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2014.11.045

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title = "Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem",

abstract = "Syringaresinol exists either exclusively as one enantiomer or enantiomeric mixtures in plant foods. We found that (+)-syringaresinol, but not (-)-syringaresinol, upregulates silent information regulator two ortholog 1 (SIRT1) gene expression, and thus, Panax ginseng berry with predominantly high contents of (+)-syringaresinol exhibits higher activity in inducing SIRT1 gene expression than Acanthopanax senticosus Harms stem with almost equal proportion of the two enantiomers. These findings highlight the importance of the absolute configuration of syringaresinol for the biological activity.",

keywords = "Acanthopanax senticosus Harms stem, Enantiomer, Panax ginseng berry pulp, SIRT1, Syringaresinol",

author = "Park, {Hyun Woo} and Cho, {Si Young} and Kim, {Hyun Hee} and Yun, {Bong Sik} and Kim, {Jeong Un} and Lee, {Sang Jun} and Jiyong Park",

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doi = "10.1016/j.bmcl.2014.11.045",

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AU - Park, Hyun Woo

AU - Cho, Si Young

AU - Kim, Hyun Hee

AU - Yun, Bong Sik

AU - Kim, Jeong Un

AU - Lee, Sang Jun

AU - Park, Jiyong

PY - 2015/1/15

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N2 - Syringaresinol exists either exclusively as one enantiomer or enantiomeric mixtures in plant foods. We found that (+)-syringaresinol, but not (-)-syringaresinol, upregulates silent information regulator two ortholog 1 (SIRT1) gene expression, and thus, Panax ginseng berry with predominantly high contents of (+)-syringaresinol exhibits higher activity in inducing SIRT1 gene expression than Acanthopanax senticosus Harms stem with almost equal proportion of the two enantiomers. These findings highlight the importance of the absolute configuration of syringaresinol for the biological activity.

AB - Syringaresinol exists either exclusively as one enantiomer or enantiomeric mixtures in plant foods. We found that (+)-syringaresinol, but not (-)-syringaresinol, upregulates silent information regulator two ortholog 1 (SIRT1) gene expression, and thus, Panax ginseng berry with predominantly high contents of (+)-syringaresinol exhibits higher activity in inducing SIRT1 gene expression than Acanthopanax senticosus Harms stem with almost equal proportion of the two enantiomers. These findings highlight the importance of the absolute configuration of syringaresinol for the biological activity.

KW - Acanthopanax senticosus Harms stem

KW - Enantiomer

KW - Panax ginseng berry pulp

KW - SIRT1

KW - Syringaresinol

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Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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