Enantiodiscrimination using a chiral crown ether as a chiral solvating agent using NMR spectroscopy

Wonjae Lee, Eunjung Bang, Ji Hye Yun, Man Jeong Paik, Weontae Lee

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


For enantiomer separation of a variety of chiral compounds, a number of chiral selectors have been developed and applied. Among these chiral selectors are chiral crown ethers, a class of synthetic polyether molecules that bind protonated chiral primary amines with high selectivity. This article focuses on enantiodiscrimination using (18-crown-6)-2,3,11,12-tetracar-boxylic acid as a crown ether-type chiral solvating agent for nuclear magnetic resonance spectroscopic method in several chirotechnologies.

Original languageEnglish
JournalNatural product communications
Issue number5
Publication statusPublished - 2019 May

Bibliographical note

Funding Information:
support for the research, authorship, and/or publication of this article: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Ministry of Science, ICT & Future Planning (2015R1A4A1041219 and 2017R1A2B2008483).

Publisher Copyright:
© The Author(s) 2019

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine


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