TY - JOUR
T1 - Elevated serum γ-glutamyl transferase is associated with low muscle function in adults independent of muscle mass
AU - Lee, Seunghyun
AU - Song, Dawon
AU - Shin, Sungjae
AU - Hong, Namki
AU - Rhee, Yumie
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/11/1
Y1 - 2022/11/1
N2 - Objective: Elevated serum γ-glutamyl transferase (GGT), a hepatic cholestasis or liver damage marker, has been associated with low lean mass and adiposity. However, whether serum GGT can predict muscle function in adults remains unclear. The aim of this study was to determine whether an elevated serum GGT is associated with low peak weight-corrected jump power (JP) and low handgrip strength (HGS). Methods: This study included 662 individuals aged ≥50 y in the final cohort (women, 86%; mean age, 64.8 y). The primary outcome was low peak weight-corrected JP defined as <23.8 W/kg and <19W/kg in men and women, respectively, and the secondary outcome was low HGS (<28 kg in men; <18 kg in women). Results: Participants with low JP had a higher GGT level, older age, lower HGS, and higher body fat than those without low JP. Serum GGT showed a negative association with JP (adjusted β = –1.16, P = 0.005) and HGS (adjusted β = –0.92, P = 0.018). One log-unit increment in GGT was associated with elevated odds of low JP (adjusted odds ratio [aOR] 2.13, P = 0.002) after adjustment for age, sex, lean mass, and body fat percentage, particularly in individuals without hepatic steatosis (aOR, 2.30) versus those with hepatic steatosis (aOR, 0.80; Pinteraction = 0.020). Conclusion: Elevated serum GGT was associated with low muscle function in adults independent of age, muscle mass, and adiposity, indicating that serum GGT may play a role as an independent marker of muscle function.
AB - Objective: Elevated serum γ-glutamyl transferase (GGT), a hepatic cholestasis or liver damage marker, has been associated with low lean mass and adiposity. However, whether serum GGT can predict muscle function in adults remains unclear. The aim of this study was to determine whether an elevated serum GGT is associated with low peak weight-corrected jump power (JP) and low handgrip strength (HGS). Methods: This study included 662 individuals aged ≥50 y in the final cohort (women, 86%; mean age, 64.8 y). The primary outcome was low peak weight-corrected JP defined as <23.8 W/kg and <19W/kg in men and women, respectively, and the secondary outcome was low HGS (<28 kg in men; <18 kg in women). Results: Participants with low JP had a higher GGT level, older age, lower HGS, and higher body fat than those without low JP. Serum GGT showed a negative association with JP (adjusted β = –1.16, P = 0.005) and HGS (adjusted β = –0.92, P = 0.018). One log-unit increment in GGT was associated with elevated odds of low JP (adjusted odds ratio [aOR] 2.13, P = 0.002) after adjustment for age, sex, lean mass, and body fat percentage, particularly in individuals without hepatic steatosis (aOR, 2.30) versus those with hepatic steatosis (aOR, 0.80; Pinteraction = 0.020). Conclusion: Elevated serum GGT was associated with low muscle function in adults independent of age, muscle mass, and adiposity, indicating that serum GGT may play a role as an independent marker of muscle function.
KW - Handgrip strength
KW - Hepatic steatosis
KW - Jump power test
KW - Muscle function
KW - Sarcopenia
KW - γ-glutamyl transferase
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U2 - 10.1016/j.nut.2022.111813
DO - 10.1016/j.nut.2022.111813
M3 - Article
C2 - 36096057
AN - SCOPUS:85137632335
SN - 0899-9007
VL - 103-104
JO - Nutrition
JF - Nutrition
M1 - 111813
ER -
