Electronic Activation of a DNA Nanodevice Using a Multilayer Nanofilm

Hyejoong Jeong, Simona Ranallo, Marianna Rossetti, Jiwoong Heo, Jooseok Shin, Kwangyong Park, Francesco Ricci, Jinkee Hong

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

A method to control activation of a DNA nanodevice by supplying a complementary DNA (cDNA) strand from an electro-responsive nanoplatform is reported. To develop functional nanoplatform, hexalayer nanofilm is precisely designed by layer-by-layer assembly technique based on electrostatic interaction with four kinds of materials: Hydrolyzed poly(β-amino ester) can help cDNA release from the film. A cDNA is used as a key building block to activate DNA nanodevice. Reduced graphene oxides (rGOs) and the conductive polymer provide conductivity. In particular, rGOs efficiently incorporate a cDNA in the film via several interactions and act as a barrier. Depending on the types of applied electronic stimuli (reductive and oxidative potentials), a cDNA released from the electrode can quantitatively control the activation of DNA nanodevice. From this report, a new system is successfully demonstrated to precisely control DNA release on demand. By applying more advanced form of DNA-based nanodevices into multilayer system, the electro-responsive nanoplatform will expand the availability of DNA nanotechnology allowing its improved application in areas such as diagnosis, biosensing, bioimaging, and drug delivery.

Original languageEnglish
Pages (from-to)5572-5578
Number of pages7
JournalSmall
Volume12
Issue number40
DOIs
Publication statusPublished - 2016 Oct 26

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • General Chemistry
  • General Materials Science

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