Electrochemical deposition of dopamine-hyaluronic acid conjugates for anti-biofouling bioelectrodes

Semin Kim, Yohan Jang, Lindy K. Jang, Sung Hyuk Sunwoo, Tae Il Kim, Seung Woo Cho, Jae Young Lee

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Bioelectrodes have been widely used to effectively mediate electrical signals with biological systems for various biomedical applications, such as biosensors and prosthetic probes. However, the electrical properties of bioelectrodes are frequently degraded in the biological milieu due to biofouling of bioelectrode surfaces. Hence, the development of simple and effective strategies for bioelectrode surface modification is important for the mitigation of biofouling. To this end, we electrochemically modify electrodes with dopamine-conjugated hyaluronic acid (DA-HA); the modified electrodes exhibit highly hydrophilic surfaces. In addition, the electrochemical impedance of the DA-HA-modified electrodes remains similar to those of bare electrodes. The DA-HA-modified electrodes showed reduced non-specific protein adsorption and minimal adhesion of fibroblasts. Our novel electrochemical passivation of electrodes using DA-HA will contribute to the further development of fouling-resistant and biocompatible bioelectrodes. The electrodeposition of DA-HA can also be potentially applied for general surface modification of other metallic and conducting materials for various applications.

Original languageEnglish
Pages (from-to)4507-4513
Number of pages7
JournalJournal of Materials Chemistry B
Issue number23
Publication statusPublished - 2017

Bibliographical note

Funding Information:
This research was supported by the Global Research Lab Program (2013-050616), the Basic Science Research Program (2016R1A2B4007172), and the Pioneer Research Center Program (2014M3C1A3001208) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning.

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)


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