Elasticizing tissues for reversible shape transformation and accelerated molecular labeling

Taeyun Ku, Webster Guan, Nicholas B. Evans, Chang Ho Sohn, Alexandre Albanese, Joon Goon Kim, Matthew P. Frosch, Kwanghun Chung

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.

Original languageEnglish
Pages (from-to)609-613
Number of pages5
JournalNature Methods
Issue number6
Publication statusPublished - 2020 Jun 1

Bibliographical note

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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