Elasticizing tissues for reversible shape transformation and accelerated molecular labeling

Taeyun Ku; Webster Guan; Nicholas B. Evans; Chang Ho Sohn; Alexandre Albanese; Joon Goon Kim; Matthew P. Frosch; Kwanghun Chung

doi:10.1038/s41592-020-0823-y

Elasticizing tissues for reversible shape transformation and accelerated molecular labeling

Taeyun Ku, Webster Guan, Nicholas B. Evans, Chang Ho Sohn, Alexandre Albanese, Joon Goon Kim, Matthew P. Frosch, Kwanghun Chung

Yonsei Advanced Science Institute

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.

Original language	English
Pages (from-to)	609-613
Number of pages	5
Journal	Nature Methods
Volume	17
Issue number	6
DOIs	https://doi.org/10.1038/s41592-020-0823-y
Publication status	Published - 2020 Jun 1

Bibliographical note

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1038/s41592-020-0823-y

Cite this

@article{d83e4f4f67f64c3282fefd4f224bb2d4,

title = "Elasticizing tissues for reversible shape transformation and accelerated molecular labeling",

abstract = "We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.",

author = "Taeyun Ku and Webster Guan and Evans, {Nicholas B.} and Sohn, {Chang Ho} and Alexandre Albanese and Kim, {Joon Goon} and Frosch, {Matthew P.} and Kwanghun Chung",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2020",

month = jun,

day = "1",

doi = "10.1038/s41592-020-0823-y",

language = "English",

volume = "17",

pages = "609--613",

journal = "Nature Methods",

issn = "1548-7091",

publisher = "Nature Publishing Group",

number = "6",

}

TY - JOUR

T1 - Elasticizing tissues for reversible shape transformation and accelerated molecular labeling

AU - Ku, Taeyun

AU - Guan, Webster

AU - Evans, Nicholas B.

AU - Sohn, Chang Ho

AU - Albanese, Alexandre

AU - Kim, Joon Goon

AU - Frosch, Matthew P.

AU - Chung, Kwanghun

PY - 2020/6/1

Y1 - 2020/6/1

N2 - We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.

AB - We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.

UR - http://www.scopus.com/inward/record.url?scp=85084817058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85084817058&partnerID=8YFLogxK

U2 - 10.1038/s41592-020-0823-y

DO - 10.1038/s41592-020-0823-y

M3 - Article

C2 - 32424271

AN - SCOPUS:85084817058

SN - 1548-7091

VL - 17

SP - 609

EP - 613

JO - Nature Methods

JF - Nature Methods

IS - 6

ER -

Elasticizing tissues for reversible shape transformation and accelerated molecular labeling

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this